Title:
肥満症、II型糖尿病およびCNS障害の治療に有用な新規化合物
Document Type and Number:
Japanese Patent JP2005536551
Kind Code:
A
Abstract:
The present invention relates to compounds of the general formula (I), wherein P is sulfone or sulfonamide; and A, B, W, X, Y and R3 are as defined in the description; to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, and/or CNS disorders, to achieve reduction of body weight and of body weight gain.
Inventors:
Garry Johansson
Anika Jenmalm-Jensen
Catalina Bayer Rain
Anika Jenmalm-Jensen
Catalina Bayer Rain
Application Number:
JP2004530936A
Publication Date:
December 02, 2005
Filing Date:
June 19, 2003
Export Citation:
Assignee:
Biovitrum AB
International Classes:
A61K31/40; A61K31/4025; A61K31/4365; A61K31/4465; A61K31/4535; A61K31/4545; A61K31/496; A61K31/551; A61P3/04; A61P3/10; A61P25/00; A61P43/00; C07D207/12; C07D211/40; C07D211/46; C07D215/46; C07D217/22; C07D401/04; C07D409/12; C07D471/04; C07D495/04; (IPC1-7): C07D207/12; A61K31/40; A61K31/4025; A61K31/4365; A61K31/4465; A61K31/4535; A61K31/4545; A61K31/496; A61K31/551; A61P3/04; A61P3/10; A61P25/00; A61P43/00; C07D211/46; C07D215/46; C07D217/22; C07D409/12; C07D471/04; C07D495/04
Domestic Patent References:
| JP2001506646A | 2001-05-22 | |||
| JPH08503228A | 1996-04-09 | |||
| JP2000053647A | 2000-02-22 |
Foreign References:
| WO2002032863A1 | 2002-04-25 | |||
| WO2001032660A1 | 2001-05-10 | |||
| WO2001032646A2 | 2001-05-10 |
Other References:
JPN6009056581, Ｍｅｔｈｖｉｎ Ｉｓａａｃ， ｅｔ ａｌ．, Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ, 2000, １０, １７１９−１７２１頁
JPN6010046700, Ｓ． Ｍ． Ｂｒｏｍｉｄｇｅ， ｅｔ ａｌ．, "Ｎｏｖｅｌ （４−ｐｉｐｅｒａｚｉｎ−１−ｙｌｑｕｉｎｏｌｉｎ−６−ｙｌ） ａｒｙｌｓｕｌｆｏｎａｍｉｄｅｓ ｗｉｔｈ ｈｉｇｈ ａｆｆｉｎｉｔｙ ａｎｄ ｓｅｌｅｃｔｉｖｉｔｙ ｆｏｒ ｔｈｅ ５−", Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ, 2001, １１（２１）, ２８４３−２８４６頁
JPN6010046700, Ｓ． Ｍ． Ｂｒｏｍｉｄｇｅ， ｅｔ ａｌ．, "Ｎｏｖｅｌ （４−ｐｉｐｅｒａｚｉｎ−１−ｙｌｑｕｉｎｏｌｉｎ−６−ｙｌ） ａｒｙｌｓｕｌｆｏｎａｍｉｄｅｓ ｗｉｔｈ ｈｉｇｈ ａｆｆｉｎｉｔｙ ａｎｄ ｓｅｌｅｃｔｉｖｉｔｙ ｆｏｒ ｔｈｅ ５−", Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ, 2001, １１（２１）, ２８４３−２８４６頁
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga