A new molecular entity which checks HIF-1alpha activity, and a manufacturing method for the same

Japanese Patent JP6054402

B2

The present invention relates to novel compounds as HIF-1α inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1α, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1α-mediated VEGFA expression.

Lee, Kyung
Won, My Son
Kim, Fan-Muk
Park, Song-Gyu
Lee, Ki-ho
Lee, Chang-U
Kim, Po-Kyung
Bread, Hyun-Sung
Jeong, Kyung-Suk
Ravi, Nike

JP2014533208A

December 27, 2016

September 27, 2012

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DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

C07C235/20; A61K31/165; A61K31/341; A61K31/495; A61K31/4985; A61K31/5375; A61K31/54; A61P3/10; A61P19/02; A61P27/02; A61P29/00; A61P43/00; C07C231/02; C07C235/22; C07D265/30; C07D279/12; C07D295/185; C07D307/52; C07D487/04

JP2002503239A

WO2008004798A1

Journal of Medicinal Chemistry,2008年,Vol. 51, No. 8,2346-2349
Journal of Medicinal Chemistry,2007年,Vol. 50, No. 7,1675-1684
Bioorganic & Medicinal Chemistry Letters,2007年,Vol. 17,6305-6310

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