Title:
A new nitroso compound and directions for use for the same as a nitroglycerine Xyl donor
Document Type and Number:
Japanese Patent JP6192016
Kind Code:
B2
Abstract:
The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
Inventors:
Frost, lisa, marie
Courtney, stephan, martin
Brookfield, frederick, arthur
Kalish, Vincent, Jay.
Courtney, stephan, martin
Brookfield, frederick, arthur
Kalish, Vincent, Jay.
Application Number:
JP2014235732A
Publication Date:
September 06, 2017
Filing Date:
November 20, 2014
Export Citation:
Assignee:
Cardioxol Pharmaceuticals, Inc.
International Classes:
C07D211/58; C07C207/04; C07C255/19; C07D309/14; C07D333/42; C07D405/12; C07D405/14; C07D407/12; C07D451/10; C07F9/09; C07F9/59; C07H13/06
Domestic Patent References:
| JP5654450B2 |
Foreign References:
| WO2007120839A2 |
Other References:
KRZHIZHEVSKII, A. M., et al.,Reactions of polyfluoronitroalkanes containing an active hydrogen atom,Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,ロシア,1974年,No.11,pp.2513-2517
KRYUKOV, L. N., et al.,Phosphoryl derivatives of geminal nitrosohexafluoro-2-propanol,Doklady Akademii Nauk SSSR,ロシア,1979年,Vol.247, No.1,pp.115-117
KRYUKOV, L. N., et al.,Phosphoryl derivatives of geminal nitrosohexafluoro-2-propanol,Doklady Akademii Nauk SSSR,ロシア,1979年,Vol.247, No.1,pp.115-117
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Mizuhara Masahiro
Nagatoshi Shinagawa
Mizuhara Masahiro
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