Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
新規ピペリジンカルボキサミド化合物、その調製方法及び使用
Document Type and Number:
Japanese Patent JP6535007
Kind Code:
B2
Abstract:
The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.

Inventors:
Joan Woo
Lee Thorn
Zon Yentuin
Xiao Jing Hai
Zhou Symbo
Juyoung Jee Bean
Lee Shenzhou
Warn Shaokui
Application Number:
JP2016541341A
Publication Date:
June 26, 2019
Filing Date:
December 19, 2014
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.A.A. China
International Classes:
C07D401/04; A61K31/404; A61K31/506; A61K31/517; A61K31/5377; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P31/04; A61P35/00; A61P37/06; A61P43/00; C07D401/14; C07D409/14
Domestic Patent References:
JP2009520019A
JP2004509108A
JP2010503686A
JP2010508274A
JP2011518836A
JP2013513628A
JP2013519701A
JP2004524282A
JP2013532727A
JP2013540750A
JP2005529078A
JP2009507896A
JP2009543805A
JP2012082175A
JP2005514365A
JP2006528213A
JP2007505092A
JP2009522223A
JP2003507456A
Foreign References:
WO2011130515A1
WO2009106561A1
WO2012069852A1
WO2012078777A1
US20030114517
WO2008008895A1
WO2010119881A1
US20100331294
WO2014175621A1
WO2014131855A1
WO2015090226A1
Other References:
RN 1261234-84-7 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 2月 1日,検索日: 15 MAR 2018
RN 1261233-55-9 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 2月 1日,検索日: 15 MAR 2018
RN 1261234-79-0 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 2月 1日,検索日: 15 MAR 2018
RN 1261232-35-2 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 2月 1日,検索日: 15 MAR 2018
RN 1353989-76-0 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 1月24日,検索日: 15 MAR 2018
RN 1483642-33-6 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2013年11月29日,検索日: 14 MAR 2018
RN 1455212-94-8, 1456045-37-6, 1458232-59-1 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2013年10月,検索日: 14 MAR 2018
RN 874832-34-5 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2006年 2月21日,検索日: 14 MAR 2018
RN 931316-35-7, 931752-91-9 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2007年 4月,検索日: 14 MAR 2018
RN 1147677-35-7, 1147712-98-8, 1147713-00-5, 1147748-79-5, 1147748-82-0, 1147748-83-1, 1147841-13-1, 1147841-15-3, 1147841-16-4 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2009年 5月20日,検索日: 14 MAR 2018
RN 1197584-45-4, 1197638-74-6, 1197801-91-4, 1197875-30-1 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2009年12月16日,検索日: 14 MAR 2018
RN 1210224-07-9 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2010年 5月16日,検索日: 14 MAR 2018
RN 1222933-18-7, 1223455-88-6, 1223473-29-7, 1223622-51-2 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2010年 5月,検索日: 14 MAR 2018
RN 1258729-41-7 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 1月 7日,検索日: 14 MAR 2018
RN 1261230-32-3, 1261231-10-0, 1261231-11-1, 1261232-45-4, 1261232-93-2, 1261234-07-4, 1261234-47-2, 1261235-45-3, 1261235-48-6, 1261236-04-7, 1261236-13-8 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 2月 1日,検索日: 14 MAR 2018
RN 1269075-42-4 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 3月21日,検索日: 14 MAR 2018
RN 1279229-16-1 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 4月13日,検索日: 14 MAR 2018
RN 1288991-56-9, 1289006-89-8, 1289147-81-4, 1289160-58-2 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 5月 2日,検索日: 14 MAR 2018
RN 1294458-31-3, 1295111-28-2, 1295111-34-0, 1296968-66-5, 1298516-49-0, 1298560-78-7, 1299857-62-7, 1301000-37-2, 1301418-30-3, 1301418-32-5, 1301418-57-4, 1301432-49-4, 1302055-36-2 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 5月,検索日: 14 MAR 2018
RN 1304066-82-7, 1304873-97-9 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 6月,検索日: 14 MAR 2018
RN 1311577-71-5, 1311777-85-1, 1311889-76-5 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 7月 7日,検索日: 14 MAR 2018
RN 1326836-47-8 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 9月 2日,検索日: 14 MAR 2018
RN 1333567-29-5 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2011年 9月28日,検索日: 14 MAR 2018
RN 1353946-01-6, 1353946-56-1, 1353956-57-6, 1353978-27-4, 1353980-23-0 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 1月24日,検索日: 14 MAR 2018
RN 1355832-32-4, 1355838-18-4 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 2月 8日,検索日: 14 MAR 2018
RN 1370947-45-7 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 4月29日,検索日: 14 MAR 2018
RN 1372140-78-7 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 5月 1日,検索日: 14 MAR 2018
RN 1379204-80-4 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 6月17日,検索日: 14 MAR 2018
RN 1488738-33-5 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2013年12月 6日,検索日: 14 MAR 2018
RN 1384703-12-1 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 7月27日,検索日: 14 MAR 2018
RN 1389483-17-3, 1389843-24-6, 1389997-41-4, 1390302-17-6 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 8月,検索日: 14 MAR 2018
RN 1394660-99-1 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 9月18日,検索日: 14 MAR 2018
RN 1420816-86-9, 1420860-20-3, 1420871-15-3, 1420900-15-7, 1420986-69-1, 1420988-35-7 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2013年 2月,検索日: 14 MAR 2018
RN 1436021-76-9, 1436027-81-4, 1436290-73-1, 1436295-25-8, 1436309-44-2, 1436325-15-3, 1436342-90-3, 1436361-07-7 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2013年 6月 9日,検索日: 14 MAR 2018
BRYAN, M. C. ET AL,Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies,ACS Combinatorial Science,2013年 8月 8日,15(9),503-511
XIAO, J. ET AL,Discovery, Synthesis, and Biological Evaluation of Novel SMN Protein Modulators,Journal of Medicinal Chemistry,2011年,54(18),6215-6233
RN 1380170-64-8 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2012年 6月26日,検索日: 14 MAR 2018
RN 1444587-69-2, 1445349-66-5 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2013年 7月,検索日: 14 MAR 2018
RN 1448030-57-6, 1448045-00-8, 1448045-66-6, 1448050-51-8, 1448050-66-5, 1448052-59-2, 1448056-70-9, 1448056-76-5, 1448058-31-8, 1448064-26-3, 1448065-27-7, 1448065-47-1, 1448066-35-0, 1448070-48-1, 1448073-65-1, 1448074-83-6, 1448123-39-4, 1448125-08-3, 1448129-18-7, 1448129-25-6, 1448132-86-2, 1448132-95-3 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2013年 8月,検索日: 14 MAR 2018
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Tatsunori Ikeda