Title:
アミノ酸誘導体の新規な調製方法
Document Type and Number:
Japanese Patent JP2012508162
Kind Code:
A
Abstract:
The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II).
Inventors:
Bowvie, Didier
Marciale, Alain
Pinilla, Veronique
Haman, Jorg
Kanzler, Ralf
Thomas, Antoine
Marciale, Alain
Pinilla, Veronique
Haman, Jorg
Kanzler, Ralf
Thomas, Antoine
Application Number:
JP2011533631A
Publication Date:
April 05, 2012
Filing Date:
November 06, 2009
Export Citation:
Assignee:
Woozebe Pharma Goemu Beha
International Classes:
C07C231/20; C07C231/02; C07C231/14; C07C237/22; C07B55/00; C07B57/00
Domestic Patent References:
| JPS61197530A | 1986-09-01 | |||
| JP2007510630A | 2007-04-26 |
Foreign References:
| WO2007076306A1 | 2007-07-05 |
Other References:
JPN6013046581; Ｂｅｇｕｉｎ， Ｃｅｃｉｌｅ ｅｔ ａｌ: 'Ｎ-Ｓｕｂｓｔｉｔｕｔｅｄ ａｍｉｎｏ ａｃｉｄ Ｎ'-ｂｅｎｚｙｌａｍｉｄｅｓ： ｓｙｎｔｈｅｓｉｓ， ａｎｔｉｃｏｎｖｕｌｓａｎｔ， ａｎｄ ｍｅｔａｂｏｌｉｃ ａｃｔｉｖｉｔｉｅｓ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１２， Ｎｏ．１１, 2004, ｐ．３０７９-３０９６
JPN6013046583; Ａｎｄｕｒｋａｒ， Ｓｈｒｉｄｈａｒ Ｖ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ａｎｔｉｃｏｎｖｕｌｓａｎｔ ａｃｔｉｖｉｔｉｅｓ ｏｆ （Ｒ）-（Ｏ）-ｍｅｔｈｙｌｓｅｒｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ Ｖｏｌ．９， Ｎｏ．２１, 1998, ｐ．３８４１-３８５４
JPN5012017049; ＣＨＯＩ Ｄ: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＡＮＴＩＣＯＮＶＵＬＳＡＮＴ ＡＣＴＩＶＩＴＩＥＳ ＯＦ Ｎ-ＢＥＮＺＹＬ-２-ＡＣＥＴＡＭＩＤＯＰＲＯＰＲＩＯＮＡＭＩＤＥ ＤＥＲＩＶＡＴＩＶＥＳ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ３９ Ｎ９, 19960101, Ｐ１９０７-１９１６, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN6013046579; 社団法人 日本化学会: 光学異性体の分離〔季刊 化学総論 Ｎｏ．６〕 , 19990610, ｐ．１４， ５８-５９， １３２， １３４-１３６， １４１, 株式会社 学会出版センター
JPN6013046583; Ａｎｄｕｒｋａｒ， Ｓｈｒｉｄｈａｒ Ｖ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ａｎｔｉｃｏｎｖｕｌｓａｎｔ ａｃｔｉｖｉｔｉｅｓ ｏｆ （Ｒ）-（Ｏ）-ｍｅｔｈｙｌｓｅｒｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ Ｖｏｌ．９， Ｎｏ．２１, 1998, ｐ．３８４１-３８５４
JPN5012017049; ＣＨＯＩ Ｄ: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＡＮＴＩＣＯＮＶＵＬＳＡＮＴ ＡＣＴＩＶＩＴＩＥＳ ＯＦ Ｎ-ＢＥＮＺＹＬ-２-ＡＣＥＴＡＭＩＤＯＰＲＯＰＲＩＯＮＡＭＩＤＥ ＤＥＲＩＶＡＴＩＶＥＳ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ３９ Ｎ９, 19960101, Ｐ１９０７-１９１６, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN6013046579; 社団法人 日本化学会: 光学異性体の分離〔季刊 化学総論 Ｎｏ．６〕 , 19990610, ｐ．１４， ５８-５９， １３２， １３４-１３６， １４１, 株式会社 学会出版センター
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Katsuhiko Shimomura
Shinichi Inoue
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Katsuhiko Shimomura
Shinichi Inoue