Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
A new preparing method of an amino acid derivative
Document Type and Number:
Japanese Patent JP6272250
Kind Code:
B2
Abstract:
The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II).

Inventors:
Bowvie, Didier
Marciale, Alain
Pinilla, Veronique
Haman, Jorg
Kanzler, Ralf
Thomas, Antoine
Application Number:
JP2015023801A
Publication Date:
January 31, 2018
Filing Date:
February 10, 2015
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UCB PHARMA GMBH
International Classes:
C07C231/20; A61K31/165; A61P25/02; A61P25/04; A61P25/08; C07B55/00; C07B57/00; C07C231/12; C07C237/22
Domestic Patent References:
JP5944354A
JP6251652A
JP2016188245A
Foreign References:
US5773475
WO2007076306A1
Other References:
Daeock Choi 他2名著、「Synthesis and Anticonvulsant Activities of N-Benzyl-2-acetamidopropionamide derivatives」、J.Med.Chem.、American Chemical Society、Vol.39、No.9、1996年、第1907~1916頁
社団法人 日本化学会編、「光学活性体の分離〔季刊 化学総説 No.6〕」、株式会社 学会出版センター、1999年6月10日初版3刷、第14、58、59、66、132、134~136、141頁
社団法人 日本化学会編、「化学便覧 応用化学編 第5版」丸善株式会社、平成7年3月15日、第II-567~II-571頁
Attorney, Agent or Firm:
Asamura patent office