Title:
The new substituted indole derivative as a gamma-secretase regulation agent
Document Type and Number:
Japanese Patent JP6068464
Kind Code:
B2
Abstract:
The present invention is concerned with novel substituted indole derivatives of Formula (I) wherein R1, R2, R3, A1, A2, A3, Y and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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Inventors:
Mine, Galette, Barlond
Bischoff, Francois Paul
Jissen, Henrix, Jacobs, Maria
Belter, adriana, ingrid
Pieters, Serge, Maria, Aloysius
Berthelot, Didier, Jean-Claude
Bischoff, Francois Paul
Jissen, Henrix, Jacobs, Maria
Belter, adriana, ingrid
Pieters, Serge, Maria, Aloysius
Berthelot, Didier, Jean-Claude
Application Number:
JP2014519557A
Publication Date:
January 25, 2017
Filing Date:
July 12, 2012
Export Citation:
Assignee:
Janssen Pharmaceuticals, Inc.
Cellsome Limited
Cellsome Limited
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/4985; A61K31/5383; A61K31/553; A61P25/16; A61P25/28; C07D487/04; C07D498/04; C07D519/00
Foreign References:
| WO2010114971A1 | ||||
| WO2010126745A1 | ||||
| WO2010098487A1 | ||||
| WO2010098495A1 |
Other References:
Trends In Pharmacological Sciences,2010年,Vol.31(9),p.402-410
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Takayuki Imazato
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Takayuki Imazato
Yasuhito Suzuki