Title:
【発明の名称】肺高血圧症およびその他の適応症用の一酸化窒素供与化合物および医薬組成物
Document Type and Number:
Japanese Patent JP2002511838
Kind Code:
A
Abstract:
The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a mucosa, where the nitric oxide is released for passage across the epithelial monolayer of the mucous membrane. The NO donor compounds include polyalkyleneamine NO donors as well as tertiary and quaternary amino aliphatic NO donor compounds. The compounds and compositions of the invention are useful in any situation in which it is desirable to deliver NO across a mucosal surface. For example, the compounds and compositions of the invention are particularly useful in treating pulmonary hypertension, male impotence, and several other specific conditions.
Inventors:
Zalzman, Andrew, Elle.
Suzabo, cassava
Roselle, Dominique, Shee.
Buri, Richard, Jay.
Jacobs, Bryan
Smith, Daniel, Jay.
Suzabo, cassava
Roselle, Dominique, Shee.
Buri, Richard, Jay.
Jacobs, Bryan
Smith, Daniel, Jay.
Application Number:
JP52172398A
Publication Date:
April 16, 2002
Filing Date:
November 05, 1997
Export Citation:
Assignee:
Children's Hospital Medical Center
The University of Akron
The University of Akron
International Classes:
A61K8/00; A61K8/41; A61K31/13; A61K31/131; A61K31/15; A61P1/02; A61P9/00; A61P11/00; A61P15/00; A61P15/10; A61P43/00; A61Q11/00; C07C243/42; C07C291/04; C08F8/30; C08G73/02; (IPC1-7): C07C291/04; A61K7/16; A61K31/13; A61K31/15; A61P1/02; A61P9/00; A61P11/00; A61P15/00; A61P15/10; A61P43/00; C07C243/42
Attorney, Agent or Firm:
Akira Asamura (3 outside)