Title:
ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
Document Type and Number:
Japanese Patent JP2005539089
Kind Code:
A
Abstract:
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.
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Inventors:
Earl Richard A.
Ezawa Maiko
Fan syncin
Garvey David S.
Gaston Ricky Dee.
Kuhanapur Subhash Pee.
Let's Gordon El.
Lin Chia-en
Rana Tunghe Ramani.
Richardson Stewart K.
Schroeder Joseph Dee.
Steveson Cherie.
Way Show-Gee
Ezawa Maiko
Fan syncin
Garvey David S.
Gaston Ricky Dee.
Kuhanapur Subhash Pee.
Let's Gordon El.
Lin Chia-en
Rana Tunghe Ramani.
Richardson Stewart K.
Schroeder Joseph Dee.
Steveson Cherie.
Way Show-Gee
Application Number:
JP2004562619A
Publication Date:
December 22, 2005
Filing Date:
July 03, 2003
Export Citation:
Assignee:
Nitromed Incorporated
International Classes:
A61K31/21; A61K31/405; A61K31/445; A61K45/00; A61P1/00; A61P1/04; A61P1/10; A61P1/14; A61P3/04; A61P17/02; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07C203/04; C07C205/40; C07C205/56; C07C219/10; C07C229/42; C07C235/08; C07C235/12; C07C235/34; C07C235/42; C07C237/08; C07C243/28; C07C271/16; C07C271/64; C07C291/02; C07C311/17; C07C317/18; C07C317/32; C07C317/46; C07C323/12; C07C327/28; C07D209/18; C07D209/28; C07D295/08; C07D211/22; C07D211/56; C07D493/04; C07F9/40; (IPC1-7): C07C203/04; A61K31/21; A61K31/405; A61K31/445; A61K45/00; A61P1/00; A61P1/04; A61P1/10; A61P1/14; A61P3/04; A61P17/02; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07C205/40; C07C205/56; C07C219/10; C07C229/42; C07C235/08; C07C235/12; C07C235/34; C07C235/42; C07C237/08; C07C243/28; C07C271/16; C07C271/64; C07C317/18; C07C317/32; C07C317/46; C07C327/28; C07D209/28; C07D211/22; C07D295/08; C07D493/04; C07F9/40
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi