Title:
肝線維症および肝硬変に対する阻害活性を示す新規ベンゾピラン誘導体とその医薬的用途
Document Type and Number:
Japanese Patent JP5349800
Kind Code:
B2
Abstract:
The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.
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Inventors:
Gon Yunde
So Jin Soo
John Moon Cook
Quack Wee John
Cho Yong Bike
Lee Nam Cue
Lee Yun Joo
Lee Jun Bum
Lee Jun Won
Lee Suk Ho
Don misuk
Kim john run
So Jin Soo
John Moon Cook
Quack Wee John
Cho Yong Bike
Lee Nam Cue
Lee Yun Joo
Lee Jun Bum
Lee Jun Won
Lee Suk Ho
Don misuk
Kim john run
Application Number:
JP2007549232A
Publication Date:
November 20, 2013
Filing Date:
June 15, 2005
Export Citation:
Assignee:
SK CHEMICALS CO.,LTD.
KOREA GAS CORPORATION
KOREA GAS CORPORATION
International Classes:
C07D311/70; A61K31/352; A61K31/453; A61K31/496; A61P1/16; A61P11/00; A61P13/12; A61P17/00; C07D405/12
Foreign References:
| US6323238 | ||||
| WO2004050082A1 |
Other References:
SKINNER,W.A. et al,Structure-activity relations in the vitamin E series. I. Effects of 5-methyl substitution on 6-hydroxy-2,2,5,7,8-pentamethylchroman,Journal of Medicinal Chemistry,1967年,Vol.10, No.4,p.657-661
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
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