Title:
新たな結晶形態の血管漏出ブロッカー化合物
Document Type and Number:
Japanese Patent JP7220931
Kind Code:
B2
Abstract:
The present invention relates to a crystalline form of (E)-methyl 6-((3S,8S,9S,10R,13S,14S,17R)-3-(((5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta [a]phenanthrene-17-yl) hept-5-enoate and a blood vessel leak blocker comprising the same. The novel crystalline form has high purity, excellent stability, excellent long-term storage and pharmaceutical stability, and can be used as a vascular leakage blocker, so it is very advantageous in producing high-quality drug substances.
Inventors:
Ahn Gu-hyun
Kim Myung Hwa
Pyo Jung-in
Baek Chors
Kim Seon Hwa
Kim Myung Hwa
Pyo Jung-in
Baek Chors
Kim Seon Hwa
Application Number:
JP2021542132A
Publication Date:
February 13, 2023
Filing Date:
October 05, 2020
Export Citation:
Assignee:
CURACLE CO., LTD.
International Classes:
A61K31/575; C07J17/00; A61P1/04; A61P3/06; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P11/08; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P37/02
Domestic Patent References:
| JP2013509401A |
Foreign References:
| KR101481709B1 |
Other References:
STAHLY,P.,医薬品の塩選択,結晶多形のスクリーニングの重要性について,薬剤学,2006年,Vol.66,No.6,p.435-439
Attorney, Agent or Firm:
Saegusa International Patent Office