Title:
簡単な組成及び高い生物有効性を有する経口投与のためのシクロスポリンの新規処方物及びその製造法
Document Type and Number:
Japanese Patent JP3833248
Kind Code:
B2
Abstract:
The invention relates to formulations of cyclosporin with high bioavailability for oral administration, which contain about 1 part by weight of one or more cyclosporin(s), preferably cyclosporin A and/or cyclosporin G, 7.5 to 7.8 parts by weight of one or more polyethylene glycol esters of saturated C10-C22hydroxy fatty acids, 0.7 to 0.85 part by weight of a monohydric alcohol as co-solvent, and 0.7 to 0.8 part by weight of a polyhydric alcohol as co-solvent. The drug form is produced by initially dissolving the cyclosporin in ethanol and, while stirring, adding propylene glycol and SOLUTOL(R) HS 15 until a clear, viscous solution results, bottled as drinkable solution or packed into capsules.
Inventors:
Matthias Olbrich
Heinrich Petter
Heinrich Petter
Application Number:
JP51493496A
Publication Date:
October 11, 2006
Filing Date:
July 19, 1995
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
International Classes:
A61K9/08; A61K9/107; A61K38/00; A61K9/48; A61K38/13; A61K47/10; A61K47/14; A61P37/00; A61P37/06
Domestic Patent References:
| JP3115227A | ||||
| JP54132223A |
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Kyousei Tamura