Title:
カンプトテシンの新規な同族体、その製造方法、その医薬としての用途及びこれを含有する医薬組成物
Document Type and Number:
Japanese Patent JP3576171
Kind Code:
B2
Abstract:
Camptothecin analogues where the camptothecin hydroxy lactone is: (i) a beta -hydroxy lactone; or (ii) the corresp. beta -hydroxy acid resulting from ring-opening of the aforementioned lactone; or a (iii) deriv. of the beta -hydroxy acid in (ii) or its one of its salts. Also claimed are new industrial prods. of formula (M) and (A). R1 = lower alkyl, lower alkenyl, lower alkynyl, halo(lower alkyl), lower alkoxy(lower alkyl) or lower alkylthio(lower alkyl); R20 = H or halo; R22 = F, Cl, or lower alkoxy; R23 = prim. hydroxy-protecting gp.; and R18, R19 = H, halo, lower alkyl, lower alkoxy or OH.
Inventors:
Big, dennis
Olivier, Ravuelne
Pla Rodas, Franchiesca
Pomier, jack
Yuri Bali, The General
Olivier, Ravuelne
Pla Rodas, Franchiesca
Pomier, jack
Yuri Bali, The General
Application Number:
JP50364497A
Publication Date:
October 13, 2004
Filing Date:
June 21, 1996
Export Citation:
Assignee:
Société de Conseille de Luciersier et Daat Precursion Syante Fitzuk
International Classes:
A61K31/47; A61K31/4745; A61K31/475; A61K31/496; A61K31/5377; A61P31/12; A61P33/00; A61P33/02; A61P35/00; A61P43/00; C07D213/02; C07D213/61; C07D213/64; C07D213/66; C07D215/08; C07D413/10; C07D471/14; C07D487/04; C07D491/04; C07D491/044; C07D491/22; C07D498/14; C07D209/00; C07D221/00; C07D313/00; (IPC1-7): C07D471/14; A61K31/47; A61P31/12; A61P35/00; A61P43/00; C07D213/61; C07D213/64; C07D491/04; C07D491/22
Foreign References:
| WO1994011376A1 |
Attorney, Agent or Firm:
Motohiro Kurauchi
Hiroshi Kazama
Hiroshi Kazama