Title:
A novel indene derivative, a method for preparing the same, and a pharmaceutical composition containing the novel indene derivative as an active ingredient for preventing or treating retinal diseases.
Document Type and Number:
Japanese Patent JP6356334
Kind Code:
B2
Abstract:
The present invention relates to a novel indene derivative, a preparation method for the same, and a pharmaceutical composition for preventing or treating retinal disease comprising the same as an active ingredient. The novel indene derivative of the present invention, the optical isomer of the same, or the pharmaceutically acceptable salts of the same have excellent inhibitory efficiency of receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Therefore, the composition containing the same as an active ingredient can be effectively used as a pharmaceutical composition for preventing or treating retinal disease exemplified by retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardts disease, Usher syndrome, choroideremia, rod-cone or cone-rod dystrophy, ciliopathy, mitochondrial disorders, progressive retinal atrophy, degenerative retinal diseases, age-related macular degeneration (AMD), wet AMD, dry AMD, geographical atrophy, inherited or acquired macular degeneration, retinal photoreceptor diseases, retinal pigment epithelial diseases, diabetic retinopathy, cystic macular edema, uveitis, retinal detachment, traumatic retinal injury, iatrogenic retinal injury, macular holes, macular capillarectasia, ganglion cell diseases, optic nerve diseases, glaucoma, optic neuropathy, ischemic retinal diseases, retinopathy of prematurity, occlusion of retinal vessels, inherited macroaneurysm, retinal vascular diseases, ophthalmic vascular diseases, glaucomatous retinal neurodegeneration, ischemic optic neuropathy and the like.
More Like This:
Inventors:
Kim, Eun Hee
Yoo Sun
Kang, Nam Souk
Coe, Tae Sun
Park, Min-Yoon
Kim, Yun-Horn
Bae Hyun-ju
Kim, Jin-Woo
In, tech
Joe, Chou-ki
Yoo Sun
Kang, Nam Souk
Coe, Tae Sun
Park, Min-Yoon
Kim, Yun-Horn
Bae Hyun-ju
Kim, Jin-Woo
In, tech
Joe, Chou-ki
Application Number:
JP2017505557A
Publication Date:
July 11, 2018
Filing Date:
July 21, 2015
Export Citation:
Assignee:
The Industry and Academic Co-operation in Chunham National University (IAC)
International Classes:
C07D495/04; A23L33/10; A61K31/4025; A61K31/41; A61K31/4453; A61K31/496; A61K31/5377; A61K31/541; A61K31/553; A61P27/02; A61P27/06; A61P43/00; C07D235/24; C07D307/85; C07D333/58; C07D333/70; C07D333/74; C07D409/04; C07D409/06; C07D413/06
Domestic Patent References:
| JP2008503511A | ||||
| JP2006522812A | ||||
| JP2004509059A | ||||
| JP2006503827A | ||||
| JP2009542679A | ||||
| JP2004512324A |
Other References:
Bioorganic & Medicinal Chemistry Letters,2004年,Vol.14, No.21,p.5251-5256
Russian Chemical Bulletin,2009年,Vol.58, No.6,p.1276-1280
Synlett,2012年,Vol.23, No.8,p.1175-1180
Acta Chimica Sinica,1962年,Vol.28, No.4,p.236-43
Database REGISTRY,2000年,RN 277299-16-8, Retrieved from STN international [online] ;retrieved on 17 Octover 2017
Database REGISTRY,2004年,RN 758701-50-7, Retrieved from STN international [online] ;retrieved on 17 Octover 2017
Database REGISTRY,2005年,RN 838887-57-3, Retrieved from STN international [online] ;retrieved on 17 Oct 2017
Russian Chemical Bulletin,2009年,Vol.58, No.6,p.1276-1280
Synlett,2012年,Vol.23, No.8,p.1175-1180
Acta Chimica Sinica,1962年,Vol.28, No.4,p.236-43
Database REGISTRY,2000年,RN 277299-16-8, Retrieved from STN international [online] ;retrieved on 17 Octover 2017
Database REGISTRY,2004年,RN 758701-50-7, Retrieved from STN international [online] ;retrieved on 17 Octover 2017
Database REGISTRY,2005年,RN 838887-57-3, Retrieved from STN international [online] ;retrieved on 17 Oct 2017
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Hiramatsu Chiharu
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Hiramatsu Chiharu