Title:
自己免疫疾患の免疫療法に用いるための、自己抗原から誘導された新規なペプチド
Document Type and Number:
Japanese Patent JP3755894
Kind Code:
B2
Abstract:
PCT No. PCT/EP95/04201 Sec. 371 Date Mar. 25, 1996 Sec. 102(e) Date Mar. 25, 1996 PCT Filed Oct. 25, 1995 PCT Pub. No. WO96/13517 PCT Pub. Date May 9, 1996The present invention relates to novel peptides derived from the autoantigen HC gp-39, said peptides comprising at least one of the amino acid sequences FGRSFTLAS (SEQ ID No. 1), FTLASSETG (SEQ ID No. 2), YDDQESVKS (SEQ ID No. 3) and FSKIASNTQ (SEQ ID No. 4). The peptides resemble MHC Class II restricted T-cell epitopes present on the autoantigen HC gp-39 in articular cartilage. HC gp-39 and said peptides can be used in antigen-specific treatment of articular cartilage destruction in autoimmune diseases to induce tolerance of the immune system. The autoantigen HC gp-39 and said peptides are also suitable to induce arthritis in non-human animals, preferably mice. The invention furthermore relates to pharmaceutical compositions comprising said autoantigen and/or said peptides, a diagnostic method for the detection of autoreactive T cells in a test sample and test kits to be used in said method.
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Inventors:
Boats, Anna Maria Helena
Huerheieden, Hayes Gertos Franciscus Mari
Huerheieden, Hayes Gertos Franciscus Mari
Application Number:
JP51430696A
Publication Date:
March 15, 2006
Filing Date:
October 25, 1995
Export Citation:
Assignee:
Akzo Novel N B
International Classes:
A61K39/00; A61K38/00; G01N33/53; A61K38/04; A61K38/08; A61K38/10; A61P19/02; A61P29/00; A61P37/00; A61P37/02; A61P37/06; C07K7/00; C07K7/04; C07K7/08; C07K14/47; G01N33/564; G01N33/68
Other References:
J. Biol. Chem., 1993, Vol.268, No.34, pages 25803-10
Attorney, Agent or Firm:
Yoshio Kawaguchi