Title:
新規フェニルナフタレン誘導体、その製造方法、及びこれを含有する医薬組成物
Document Type and Number:
Japanese Patent JP2006505604
Kind Code:
A
Abstract:
1-(Amido-, ureido- or carbamoyl-alkyl)-3-(substituted methyl-phenyl)-naphthalene derivatives (I) are new. Phenyl-naphthalene derivatives of formula (I) and their enantiomers, diastereomers and acid or base addition salts are new. A = -NR2-CO-R1, -NR2-CO-NR1R'1 or -CO-NR1R'1; R1, R'1 = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-8C cycloalkyl, (3-8C) cycloalkyl-(1-6C) alkyl, aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; R2 = H or alkyl; or R1 + R2 = 3-6C linear or branched alkylene; R3 = 1-6C alkoxy; R4 = halo, OH, 1-6C alkoxy, NH2 or mono- or di-(1-6C alkyl)-amino; aryl moieties = phenyl, naphthyl or biphenylyl (all optionally substituted by 1-3 of 1-6C alkyl, 1-6C alkoxy, OH, COOH, CHO, NO2, CN, 1-6C polyhaloalkyl, alkoxycarbonyl or halo); p = 1-3; heteroaryl moieties = mono- or bicyclic aromatic group containing 1-3 of O, S and N as heteroatom(s) (optionally substituted as for aryl). Independent claims are included for: (a) the preparation of (I); and (b) new alkoxycarbonylphenyl-naphthalene derivative intermediates of formula (V) and their enantiomers, diastereomers and acid or base addition salts. R'5 = (1-6C) alkoxycarbonyl.
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Inventors:
Poissonniere-Drew, Sophie
Yu, Side
Le surreal, daniel
Benjan, Carolyn
De Lagrange, Philip
Renard, Pierre
Yu, Side
Le surreal, daniel
Benjan, Carolyn
De Lagrange, Philip
Renard, Pierre
Application Number:
JP2004550730A
Publication Date:
February 16, 2006
Filing Date:
November 04, 2003
Export Citation:
Assignee:
Réra Bora Toir Servier
International Classes:
C07C233/18; A61K31/165; A61K31/4015; A61P1/00; A61P1/14; A61P3/00; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P15/00; A61P15/10; A61P15/18; A61P25/00; A61P25/06; A61P25/08; A61P25/16; A61P25/20; A61P25/22; A61P25/28; A61P35/00; A61P37/02; A61P43/00; C07C233/36; C07C233/60; C07D207/27; C07D207/26
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda