Title:
広域スペクトルのインフルエンザ抗ウイルス剤としての置換されたヘテロアリール基を有する新規ピペラジン類似体
Document Type and Number:
Japanese Patent JP2013542201
Kind Code:
A
Abstract:
A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with —N, —O, or —S adjacent to the —Ar substituent or adjacent to the point of attachment for the —Ar substituent; Ar is aryl or heteroaryl; R is —CH3, —CH2F, —CHF2 or —CH═CH2; V is —H, —CH3 or ═O; W is —NO2, —Cl, —Br, —CH2OH, or —CN; X is —Cl, —Br, —F, —CH3, —OCH3, or —CN; Y is —CH or —N; and Z is —CH or —N. This compound is useful in compositions for the prevention and treatment of influenza virus.
Inventors:
Christopher W Chanch
Samuel Geritz
Kim Shawn
David Earl Langley
Li Guo
Bradley Sea Pearce
Anna Pana Pendri
Shu Hao Shi
Weishui Jai
Shillong Jou
Samuel Geritz
Kim Shawn
David Earl Langley
Li Guo
Bradley Sea Pearce
Anna Pana Pendri
Shu Hao Shi
Weishui Jai
Shillong Jou
Application Number:
JP2013531678A
Publication Date:
November 21, 2013
Filing Date:
September 23, 2011
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D207/34; A61K31/496; A61K31/506; A61P31/12; A61P31/16; C07D231/22; C07D233/90; C07D249/06; C07D261/04; C07D261/18; C07D275/02; C07D413/04; C07D413/12; C07D413/14
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Mizuhara Masahiro
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Mizuhara Masahiro
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