新規チオウレア誘導体およびこれを含有する薬学的組成物

Japanese Patent JP5001505

B2

The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

Sue Yangor
Ooo Taek
Kim Hee Doo
Lee Woo
Park Hyun Kyun
Park Ok Hui
Lee Young Sil
Park Yang Ho
Joo Yang Hyap
Choi Jin Kyu
Rim Cancel
Kim San Yang
Kim Jin Kwang
Coe Hyunju
Moju Hyang
John Youngsu
Ijan Bang
Oh Yang Im

JP2002521194A

August 15, 2012

August 20, 2001

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AMOREPACIFIC CORPORATION

C07C275/24; C07D295/12; A61K31/17; A61K31/341; A61K31/36; A61K31/381; A61K31/40; A61K31/404; A61K31/417; A61K31/4184; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4965; A61K31/5375; A61K31/54; A61P3/10; A61P11/00; A61P11/06; A61P13/10; A61P17/00; A61P19/02; A61P25/00; A61P25/04; A61P25/06; A61P27/02; A61P29/00; C07C279/28; C07C311/08; C07C311/47; C07C333/20; C07C335/04; C07C335/12; C07C335/14; C07C335/20; C07C335/26; C07D207/323; C07D207/335; C07D207/416; C07D207/42; C07D209/08; C07D209/14; C07D213/40; C07D213/61; C07D213/76; C07D217/06; C07D231/14; C07D231/56; C07D233/54; C07D233/61; C07D233/64; C07D235/14; C07D239/42; C07D241/12; C07D241/24; C07D277/28; C07D279/12; C07D295/13; C07D295/215; C07D295/22; C07D295/28; C07D307/52; C07D311/58; C07D317/58; C07D333/20; C07D333/42; C07D413/12; C07D207/32; C07D207/40; C07D235/10

JP64026551A
JP2231469A
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JP5221959A
JP9502702A
JP2091057A
JP53090222A
JP4059709A
JP2209868A
JP2004506714A
JP2004504280A
JP2003506372A
JP2000281659A
JP1096180A

WO1999058497A1
WO2000034260A1
WO2001057008A1
WO2000078721A1
WO2000056681A1

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Hatsushi Shimizu

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