Title:
表情皺及び加齢による皺に対する新規な局所適用剤
Document Type and Number:
Japanese Patent JP5006789
Kind Code:
B2
Abstract:
The compounds of formula (I) wherein X represents a bond or NH—CH(C═O)—(CH2)3+n—NH—R5, n represents 0, 1 or 2, R1, R4 and R5—independently from each other—represent hydrogen, possibly substituted C1-C6-alkyl, amidino or tetra-C1-C6-alkylamidinium, R2 represents hydrogen or possibly substituted C1-C6-alkyl or R1 and R2 together with the residue to which they are bound represent a 5- to 7-membered, saturated ring, R3 represents C1-C12-alkoxy, C1-C12-alkylamino, possibly substituted aryl-C1-C6-alkylamino, possibly substituted heteroaryl-C1-C6-alkylamino, possibly substituted aryl-C1-C6-alkoxy or possibly substituted heteroaryl-C1-C6-alkoxy, and R6 represents hydrogen or, when n is 1, also amino or together with R1 and the residue to which R6 and R1 are bound a 5- to 7-membered, saturated ring, as well as their physiologically acceptable salts are new. They can be manufactured according to common methods and processed to topically applicable compositions that are appropriate for treating mimic and age-related wrinkles in human skin.
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Inventors:
Imfelt, Dominique
Ziegler, Hugo
Victor, peter
Ziegler, Hugo
Victor, peter
Application Number:
JP2007539437A
Publication Date:
August 22, 2012
Filing Date:
November 01, 2005
Export Citation:
Assignee:
DSM IP ASSETS B.V.
International Classes:
C07K5/10; A61K8/64; A61K38/00; A61P17/00; A61P21/02; A61P43/00; A61Q19/00; A61Q19/08; C07K1/06; C07K5/023; C07K5/027; C07K5/08
Domestic Patent References:
| JP2002542777A |
Foreign References:
| US4563305 | ||||
| US3966701 |
Other References:
Chem.Pharm.Bull.,Vol.39,No.3(1991)p.584-589
J.Biomater.Sci.Polym.Ed.,Vol.2,No.2(1991)p.123-138
J.Biomater.Sci.Polym.Ed.,Vol.2,No.2(1991)p.123-138
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito