Title:
抗体付きアジュバントを抗原提示細胞に直接的に標的化することをベースにした新規ワクチンアジュバント
Document Type and Number:
Japanese Patent JP2013535508
Kind Code:
A
Abstract:
Compositions and methods for enhancing an immune response with an adjuvant composition comprising: an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to at least a portion of a TLR agonist; and a pharmaceutically acceptable carrier are disclosed herein. The conjugate and agonist are each comprised in an amount such that, in combination with the other, are effective to produce the immune response in a human or animal subject in need of immunostimulation.
Inventors:
Zlauski Gerald
Banche Leia Jack F.
Flammer Ann-Roll
Banche Leia Jack F.
Flammer Ann-Roll
Application Number:
JP2013524253A
Publication Date:
September 12, 2013
Filing Date:
August 12, 2011
Export Citation:
Assignee:
BAYLOR RESEARCH INSTITUTE
International Classes:
A61K39/145; A61K39/00; A61K39/15; A61K39/155; A61K39/20; A61K39/245; A61K39/29; A61K39/39; A61K39/395; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P37/08; C07K14/005; C07K14/195; C07K14/82; C07K16/28; C07K19/00; C12N15/09
Domestic Patent References:
| JP2013525496A | 2013-06-20 | |||
| JP2006502080A | 2006-01-19 |
Foreign References:
| WO2007103048A2 | 2007-09-13 | |||
| WO2008097866A2 | 2008-08-14 |
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
High Kazuya Tsu
Makoto Horiuchi
Seiji Ozawa
Yusaku Tokai
High Kazuya Tsu
Makoto Horiuchi