Title:
新規なウイルス増殖方法およびそのためのインターフェロン欠損培養基
Document Type and Number:
Japanese Patent JP4837827
Kind Code:
B2
Abstract:
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. The invention also relates to the development and use of IFN-deficient systems for selection of such attenuated viruses. In particular, the invention relates to attenuated influenza viruses having modifications to the NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. The mutant viruses replicate in vivo but demonstrate reduced pathogenicity, and therefore are well suited for live virus vaccines, and pharmaceutical formulations.
Inventors:
Paresse, Peter
Garcia-Sus Torre, Adolfo
O'Neill, Robert
Garcia-Sus Torre, Adolfo
O'Neill, Robert
Application Number:
JP2000553560A
Publication Date:
December 14, 2011
Filing Date:
June 11, 1999
Export Citation:
Assignee:
Mount Sinai School of Medicine
International Classes:
A61K39/12; A61K35/76; C12N7/00; A61K39/00; A61K39/145; A61K39/155; A61K39/17; A61K39/205; A61K45/00; A61P31/12; A61P31/14; A61P31/16; A61P35/00; A61P37/02; C07K14/11; C12N7/01; C12N7/04; C12N15/01; C12N15/09; C12N15/86
Foreign References:
| US4071618A | 1978-01-31 | |||
| WO1997008292A1 | 1997-03-06 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Ishii Teiji