Title:
【発明の名称】コンホメーションが固定されたヌクレオシド類縁体
Document Type and Number:
Japanese Patent JPH09502986
Kind Code:
A
Abstract:
Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.
Inventors:
Marquez, Victor E.
Rodriguez, Juan Bee.
Nick Rouse, Mark See.
Birch, Joseph Jay. Jr.
Siddiki, McBurray A.
Rodriguez, Juan Bee.
Nick Rouse, Mark See.
Birch, Joseph Jay. Jr.
Siddiki, McBurray A.
Application Number:
JP50996195A
Publication Date:
March 25, 1997
Filing Date:
September 23, 1994
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
A61K31/70; A61K31/7088; A61P31/18; C07D239/46; C07D239/54; C07D239/26; C07D473/18; C07D473/34; C07H19/04; C07H21/00; (IPC1-7): C07D239/26; C07H21/00; C07D473/34; C07D473/18; A61K31/70
Attorney, Agent or Firm:
Atsushi Nakajima (4 people outside)