To provide a sustained-release pharmaceutical preparation of N-acyl pyrrolidine carbonitrile derivative having an amino group in the molecule.
In formulation of a matrix type sustained-release pharmaceutical preparation of a basic and acid-labile compound, a matrix type sustained-release pharmaceutical preparation showing pH-independent release is prepared by the use of a basic normal salt sparingly-soluble in water and an organic acid. Further, the use of the basic normal salt sparingly-soluble in water exhibits an effect of suppressing decomposition of a main drug. By dispersing the organic acid in a neutral low melting point solid, the organic acid is disposed not to come into contact with the N-acyl pyrrolidine carbonitrile derivative having an amino group in the molecule and the basic normal salt sparingly-soluble in water.
HIROSE MAYUKO
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