Title:
ペプチドセグメント縮合方法
Document Type and Number:
Japanese Patent JPH09511743
Kind Code:
A
Abstract:
The present invention is drawn to a process for forming an amide bond linkage comprising reacting a carboxylic acid and an amine in a two-phase mixture of water and an organic solvent selected from an oxygenated organic solvent or an aromatic solvent in the presence of a coupling reagent and an additive. This process is useful for making ubiquitous amides and polypeptides having various biological activities.
Inventors:
エマーソン，カテイータ
ソン，ジーグオ
ホー，グオージー
マスレ，デイビツド・エイ
ソン，ジーグオ
ホー，グオージー
マスレ，デイビツド・エイ
Application Number:
JP52637495A
Publication Date:
November 25, 1997
Filing Date:
March 31, 1995
Export Citation:
Assignee:
メルク エンド カンパニー インコーポレーテッド
International Classes:
B01J25/02; C07B61/00; C07C231/02; C07C231/18; C07C233/00; C07D211/76; C07D295/26; C07D401/06; C07D401/14; C07D453/04; C07K1/02; C07K1/06; C07K1/10; C07K5/06; C07K5/08; (IPC1-7): C07C233/00; B01J25/02; C07C231/02; C07C231/18; C07D211/76; C07D401/06; C07D401/14; C07D453/04; C07K1/02; C07K1/06; C07K1/10; C07K5/06; C07K5/08
Attorney, Agent or Firm:
川口 義雄 （外３名）