Title:
デクルシン誘導体を有効成分として含有する老化関連疾患の予防または治療用薬学組成物
Document Type and Number:
Japanese Patent JP6826674
Kind Code:
B2
Abstract:
The present invention relates to a novel decursin derivative and a composition for preventing or treating an aging-related disease comprising the same as an active ingredient. The novel decursin derivative has exhibited an excellent effect of inhibiting progerin expression and excellent effect of inhibiting binding between progerin and lamin A, and it has been confirmed that the novel decursin derivative prolongs the survival period of animal models in which progerin was induced. Therefore, a compound of the present invention can be effectively used for the prevention or treatment of aging-related diseases such as progeria, etc.
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Inventors:
Park Pom Chun
Sung Kyu Young
Good luck
Lee Ji Hyun
Yun Eunju
Sung Kyu Young
Good luck
Lee Ji Hyun
Yun Eunju
Application Number:
JP2019558763A
Publication Date:
February 03, 2021
Filing Date:
April 25, 2018
Export Citation:
Assignee:
PRG S&TECH INC.
International Classes:
A61K31/37; A61K8/49; A61P43/00; A61Q19/08
Domestic Patent References:
| JP2008001602A | ||||
| JP2008528577A | ||||
| JP2017057159A | ||||
| JP2017071632A |
Foreign References:
| KR1020100008808A | ||||
| US20140039010 | ||||
| KR101674145B1 | ||||
| KR1020080040094A |
Other References:
Kyeong Lee et al.,3D-QSAR Study of Melanin Inhibiting (S)-(+)-Decursin and its Analogues by Pharmacophore Mapping,Bull. Korean Chem. Soc.,2012年,Vol. 33, No.1,pp. 149-152
Kyeong Lee et al.,Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells,European Journal of Medicinal Chemistry,2010年,45,pp. 5567-5575
野崎正勝 等,創薬化学,株式会社化学同人,1995年,第1版,pp.98-99
Kyeong Lee et al.,Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells,European Journal of Medicinal Chemistry,2010年,45,pp. 5567-5575
野崎正勝 等,創薬化学,株式会社化学同人,1995年,第1版,pp.98-99
Attorney, Agent or Firm:
Kenji Sugimura
Mitsutsugu Sugimura
Mutsuya Yamamoto
Mitsutsugu Sugimura
Mutsuya Yamamoto