Title:
ピペラジンおよびピペリジン化合物
Document Type and Number:
Japanese Patent JP3989554
Kind Code:
B2
Abstract:
The invention relates to a group of new piperazine and piperidine compounds having interesting pharmacological properties. It has been found that compounds of formula (a) wherein A represents a heterocyclic group of 5-7 ring atoms wherein 1-3 heteroatoms from the group O, N and S are present; R1 is hydrogen or fluoro; R2 is C1-4-alkyl, C1-4-alkoxy or an oxo group, and p is 0, 1 or 2; Z represents carbon or nitrogen, and the dotted line is a single bond when Z is nitrogen, and a single or double bond when Z is carbon; R3 and R4 independently are hydrogen or C1-4-alkyl; n has the value 1 or 2; R5 is halogen, hydroxy, C1-4-alkoxy or C1-4-alkyl, and q is 0, 1, 2 or 3; Y is phenyl, furanyl or thienyl, which groups may be substituted with 1-3 substituents of the group hydroxy, halogen, C1-4-alkoxy, C1-4-alkyl, cyano, aminocarbonyl, mono- or di-C1-4-alkylaminocarbonyl; and salts thereof show high affinity for both the dopamine D2 and serotonin 5-HT1A receptors.
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Inventors:
Fernstra, Lelov Ureim
Kruze, Cornelis Gerrit
Malteinus Theodorus Maria, Toulp
Quipelus, Wilma
Long, Stephen Kenneth
Kruze, Cornelis Gerrit
Malteinus Theodorus Maria, Toulp
Quipelus, Wilma
Long, Stephen Kenneth
Application Number:
JP53488697A
Publication Date:
October 10, 2007
Filing Date:
March 20, 1997
Export Citation:
Assignee:
DUPHAR INTERNATIONAL RESEARCH BESLOTEN VENNOOTSHAP
International Classes:
C07D209/14; A61K31/00; A61K31/34; A61K31/343; A61K31/357; A61K31/42; A61K31/423; A61K31/44; A61K31/495; A61K31/496; A61K31/535; A61K31/55; A61K31/551; A61K31/5513; A61P25/04; A61P43/00; C07D209/08; C07D215/12; C07D215/38; C07D263/58; C07D265/36; C07D307/79; C07D311/06; C07D311/18; C07D317/66; C07D319/08; C07D319/14; C07D319/18; C07D321/10; C07D327/06; C07D333/54; C07D401/04; C07D403/04; C07D405/04; C07D405/14; C07D407/10; C07D407/12; C07D409/04; C07D409/10; C07D409/12; C07D411/04; C07D413/04; C07D413/10; C07D413/12; A61P25/16; A61P25/18; A61P25/22; A61P25/24
Domestic Patent References:
| JP62205058A | ||||
| JP61152666A | ||||
| JP6502183A | ||||
| JP8501559A | ||||
| JP4230362A |
Foreign References:
| WO1994013659A1 | ||||
| DE2263211A |
Attorney, Agent or Firm:
Heikichi Odashima
Heigo Odashima
Heigo Odashima