Title:
ポリ(エチレングリコール)の加水分解的に分解可能なカルバメート誘導体
Document Type and Number:
Japanese Patent JP5031164
Kind Code:
B2
Abstract:
Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.
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Inventors:
Bentley, Michael David
Chao, Shen
Chao, Shen
Application Number:
JP2001548150A
Publication Date:
September 19, 2012
Filing Date:
December 08, 2000
Export Citation:
Assignee:
Nectar Therapeutics
International Classes:
A61K9/06; C08G65/329; A61K31/77; A61K47/32; A61K47/34; A61K47/36; A61K47/42; A61K47/44; A61K47/48; A61P5/00; A61P5/38; A61P9/00; A61P25/22; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P43/00; C08L101/16
Domestic Patent References:
JP2002508400A | ||||
JP2001523637A | ||||
JP2001518528A |
Other References:
Bioconjugate Chemistry,12(2),163-169
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita