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Title:
ポリマータンパク質微粒子
Document Type and Number:
Japanese Patent JP7217247
Kind Code:
B2
Abstract:
The present invention relates to microparticles comprising a protein particle core coated with a biodegradable polymer cortex, methods of manufacturing such microparticles, and methods for modulating the release of a protein.The microparticles are used in extended release pharmaceutical formulations for use in the vitreous for the treatment of vascular eye disorders.

Inventors:
Chen Hunter
Walsh Scott
Application Number:
JP2020112359A
Publication Date:
February 02, 2023
Filing Date:
June 30, 2020
Export Citation:
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Assignee:
REGENERON PHARMACEUTICALS, INC.
International Classes:
A61K38/17; A61K9/14; A61K9/50; A61K38/22; A61K39/395; A61K47/34; A61K47/38; A61K47/64; A61K47/68; A61P27/02; A61P43/00; C07K14/705; C07K16/18; C07K17/02; C07K17/12; C07K19/00
Domestic Patent References:
JP2010522743A
Other References:
Journal of Pharmacology and Experimental Therapeut,1997年,Vol.281,No.3,p1431-1439
Toxicological Sciences,1999年,Vol.52,No.1,p101-106
Nature Medicine,1996年,Vol.2,No.7,p795-799
Molecular Vision,2005年,Vol.11,p1002-1011
European Journal of Pharmaceutics and Biopharmaceu,2004年,Vol.57,No.2,p207-212
Journal of Ocular Pharmacology and Therapeutics,2011年06月,Vol.27,No.3,p219-224
Ophthalmology,2011年06月,Vol.118,No.6,p1098-1106
Ophthalmology,2011年09月,Vol.118,No.9,p1819-1826
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto