Title:
位置特異的な生理活性ポリペプチド結合体の調製方法
Document Type and Number:
Japanese Patent JP2012520873
Kind Code:
A
Abstract:
The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations of various peptide drugs having high in-vivo activity and markedly prolonged in-blood half-life.
Inventors:
Songdehe
Shin Jae Hee
Jejemin
Park Young Kyung
Kwon Sechan
Quantum
Shin Jae Hee
Jejemin
Park Young Kyung
Kwon Sechan
Quantum
Application Number:
JP2012500720A
Publication Date:
September 10, 2012
Filing Date:
March 18, 2010
Export Citation:
Assignee:
HANMI SCIENCE CO., LTD.
International Classes:
C07K1/18; A61K47/48
Domestic Patent References:
| JP2008143897A | 2008-06-26 | |||
| JP2007526234A | 2007-09-13 |
Foreign References:
| WO2004093823A2 | 2004-11-04 | |||
| WO2006076471A2 | 2006-07-20 |
Attorney, Agent or Firm:
Iseki Katsumori
Tanaka rice
Tanaka rice