Title:
A preparing method of Benzyl benzene sodium dependency glucose cotransporter 2 (SGLT2) inhibitor
Document Type and Number:
Japanese Patent JP6208745
Kind Code:
B2
Abstract:
Provided are methods of making compounds having an inhibitory effect on sodium-dependent glucose cotransporter (SGLT) and synthetic intermediates useful for preparing such compounds.
Inventors:
Bai Shu
Lube Binhwa
Shui Gore
Brian seed
Jacks lovage
Lube Binhwa
Shui Gore
Brian seed
Jacks lovage
Application Number:
JP2015504847A
Publication Date:
October 04, 2017
Filing Date:
March 14, 2013
Export Citation:
Assignee:
Ceracos Sub, Limited Liability Company
International Classes:
C07D309/10; C07H7/04
Domestic Patent References:
| JP2010519273A | ||||
| JP2012505858A | ||||
| JP2010513564A | ||||
| JP2010536882A | ||||
| JP2006516257A | ||||
| JP2012500803A |
Foreign References:
| WO2011039108A1 | ||||
| WO2011039107A1 | ||||
| WO2006073197A1 | ||||
| WO2004013118A1 | ||||
| WO2004080990A1 |
Other References:
Wu, D. Y. et al.,Condensation of o- and p-bromobenzyl alcohols with phenol and 2,6-dibromophenol in the presence of aluminum chloride,Journal of the American Chemical Society,1951年,73,3443-3444
Huston,R.C. et al.,Bromo derivatives of benzylphenols. I. Some monobromo, dibromo and tribromo derivatives of o- and p-benzylphenols,Journal of the American Chemical Society,1933年,55,2146-2149
Xu, Baihua et al.,C-Aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes,Bioorganic & Medicinal Chemistry Letters,2011年,21(15),4465-4470.
Zhang, Wenbin et al.,EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA1c levels in db/db mice and prolongs the survival of stroke-prone rats ,Pharmacological Research,2011年,63(4),284-293
Huston,R.C. et al.,Bromo derivatives of benzylphenols. I. Some monobromo, dibromo and tribromo derivatives of o- and p-benzylphenols,Journal of the American Chemical Society,1933年,55,2146-2149
Xu, Baihua et al.,C-Aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes,Bioorganic & Medicinal Chemistry Letters,2011年,21(15),4465-4470.
Zhang, Wenbin et al.,EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA1c levels in db/db mice and prolongs the survival of stroke-prone rats ,Pharmacological Research,2011年,63(4),284-293
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Michiko Uehara
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Michiko Uehara