Title:
A preparing method of a fluorination organic compound
Document Type and Number:
Japanese Patent JP5969598
Kind Code:
B2
Abstract:
A method for preparing a fluorinated organic compound (II) from an organic compound (I) comprising at least one nucleofugal group Nu, and also a preparation of different specific organic compounds, in particular a fluoro-methylpyrazole compound. The method comprises: a reaction, in the presence of water, of the organic compound (I) and at least one salt providing at least one fluoride anion; and a replacement of at least one nucleofugal group Nu of the compound (I) with a fluorine atom, in order to obtain the fluorinated organic compound (II).
Inventors:
Olivier Bouisin
Michelle Dejou
Michelle Dejou
Application Number:
JP2014513154A
Publication Date:
August 17, 2016
Filing Date:
May 29, 2012
Export Citation:
Assignee:
RHODIA OPERATIONS
International Classes:
C07C51/363; C07C53/16; C07C53/21; C07C67/307; C07C69/63; C07C231/12; C07C233/05; C07D231/14
Domestic Patent References:
| JP64045321A | ||||
| JP2008520698A | ||||
| JP2006515601A | ||||
| JP55040609A | ||||
| JP1055261B2 | ||||
| JP2010531314A | ||||
| JP2010513411A |
Foreign References:
| WO2008134035A1 | ||||
| WO2003076366A1 | ||||
| US2403576 | ||||
| WO2010142377A1 |
Other References:
GEORGES BRAM,EASY AND EFFICIENT HETEROGENEOUS NUCLEOPHILIC FLUORINATION WITHOUT SOLVENT,SYNTHETIC COMMUNICATIONS,米国,TAYLOR AND FRANCIS INC,1988年10月 1日,V18 N14,P1661-1667
KREMSNER J M,MICROWAVE-ASSISTED ALIPHATIC FLUORINE-CHLORINE EXCHANGE USING TRIETHYLAMINE TRIHYDROFLUORIDE(TREAT-HF),TETRAHEDRON LETTERS,NL,ELSEVIER,2009年 7月 1日,V50 N26,P3665-3668
James H. Clark,Reactions of potassium fluoride in glacial acetic acid with chlorocarboxylic acids, amides, and chlorides. The effect of very strong hydrogen bonding on the nucleophilicity of the fluoride anion,JOURNAL OF THE CHEMICAL SOCIETY, DALTON TRANSACTIONS,1975年,20,P2129-2134
Dong Wook Kim,Facile Nucleophilic Fluorination Reactions Using tert-Alcohols as a Reaction Medium: Significantly Enhanced Reactivity of Alkali Metal Fluorides and Improved Selectivity,THE JOURNAL OF ORGANIC CHEMISTRY,2008年,73 (3),P957-962
KREMSNER J M,MICROWAVE-ASSISTED ALIPHATIC FLUORINE-CHLORINE EXCHANGE USING TRIETHYLAMINE TRIHYDROFLUORIDE(TREAT-HF),TETRAHEDRON LETTERS,NL,ELSEVIER,2009年 7月 1日,V50 N26,P3665-3668
James H. Clark,Reactions of potassium fluoride in glacial acetic acid with chlorocarboxylic acids, amides, and chlorides. The effect of very strong hydrogen bonding on the nucleophilicity of the fluoride anion,JOURNAL OF THE CHEMICAL SOCIETY, DALTON TRANSACTIONS,1975年,20,P2129-2134
Dong Wook Kim,Facile Nucleophilic Fluorination Reactions Using tert-Alcohols as a Reaction Medium: Significantly Enhanced Reactivity of Alkali Metal Fluorides and Improved Selectivity,THE JOURNAL OF ORGANIC CHEMISTRY,2008年,73 (3),P957-962
Attorney, Agent or Firm:
Axis International Patent Business Corporation
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