Title:
メルドニウム(Meldonium)塩、メルドニウム塩の調製方法、およびメルドニウム塩を主成分とする薬学的組成物
Document Type and Number:
Japanese Patent JP4634380
Kind Code:
B2
Abstract:
New salts of Meldonium, the method of their preparation, and pharmaceutical formulation on their basis have been described. The general formula of these salts is X-(CH3)3N+NHCH2CH2COOH where X- is an acid anion selected from the group of pharmaceutically acceptable acids. Practically non-hygroscopic and/or increased thermal stability and/or lasting action Meldonium hydrogen salts of fumaric acid, phosphoric acid, oxalic acid, maleic acid, and pamoic acid as well as Meldonium orotate and galactarate are especially suitable. Novel pharmaceutical formulations containing non-hygroscopic and/or increased thermal stability and/or and/or lasting action 3-(2,2,2-trimethylhydrazinium) propionate salts for oral parenteral, rectal, and transdermal introduction are concurrently described.
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Inventors:
Calvinche, Ivals
Billman, Anatoliju
Billman, Anatoliju
Application Number:
JP2006522512A
Publication Date:
February 16, 2011
Filing Date:
July 15, 2004
Export Citation:
Assignee:
Joint Stock Company Grindex
International Classes:
C07C243/40; A61K9/00; A61K9/52; A61K31/205; A61K47/12; A61P9/10; C07B61/00; C07C53/16; C07C55/07; C07C55/10; C07C55/14; C07C57/145; C07C57/15; C07C59/08; C07C59/265; C07C241/02; C07C243/14
Domestic Patent References:
| JP64000059A | ||||
| JP55501656A |
Foreign References:
| WO1997006795A1 |
Attorney, Agent or Firm:
Keiichi Ota