Title:
ＧＣＰＩＩ突然変異体を含有するアルツハイマーの予防及び治療用薬学的組成物
Document Type and Number:
Japanese Patent JP5584743
Kind Code:
B2
Abstract:
The present invention relates to a GCP II (glutamate carboxypeptidase II) mutant (K699S) having the activity of inhibiting glutamate production and the activity of cleavaging β-amyloid, and to a pharmaceutical composition for the prevention and treatment of a disease selected from the group consisting of amyloidosis, Alzheimer's disease, Down syndrome accompanying Alzheimer's disease, stroke, dementia, Huntington's disease, Pick's disease, and Creutzfeldt-Jakob disease comprising the GCP II mutant (K699S) as an active ingredient. The GCP II (glutamate carboxypeptidase II) mutant (K699S) demonstrates not only excellent Aβ cleavage activity compared with the wild type GCP II but also excellent activity of inhibiting glutamate production, unlike the wild type GCP II, so that the mutant has been confirmed to have higher effect and stability than the wild type, suggesting that the GCP II mutant can be effectively used for the prevention or treatment of neurodegenerative diseases.
Inventors:
Kim Hyunh John
Lee スク キョン
Park Sun イク
Ann サンミ
Lee スク キョン
Park Sun イク
Ann サンミ
Application Number:
JP2012222654A
Publication Date:
September 03, 2014
Filing Date:
October 05, 2012
Export Citation:
Assignee:
Korea Center Fau Disease Control And プリベンション
International Classes:
A61K38/46; A61K48/00; A61P25/28; C12Q1/02; C12Q1/37; C12Q1/68; G01N33/15; G01N33/50; C12N15/09
Attorney, Agent or Firm:
Spring water Original aim
Masao Haruna
Hirotaka Yamaguchi
Shun Osakabe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Osakabe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto