Title:
オキソステロイド化合物の還元による、またはハイドロキシステロイド脱水素酵素を用いるハイドロキシステロイド化合物の酸化によるステロイド誘導体の調製のためのプロセス
Document Type and Number:
Japanese Patent JP2009535017
Kind Code:
A
Abstract:
A process for the enantioselective reduction of compounds having a steroid structure (ABCD) including one or several heteroatoms, one or several double bonds and/or aromatic components in the ring structure and having at least one oxo group at positions 3, 7, 11, 12 or 17 in the steroid ring system or in the a-position of any carbon moiety of the steroid structure: comprising providing the oxosteroid compound in the reaction at a concentration of ≧50 g/L, a reduced cofactor NADH or NADPH, a hydroxysteroid dehydrogenase and a secondary alcohol or cycloalknaol to effect the enantioselective reduction.
Inventors:
Gupta, Anche
Chainer, Anke
Babcova, Maria
Chainer, Anke
Babcova, Maria
Application Number:
JP2009504633A
Publication Date:
October 01, 2009
Filing Date:
April 11, 2007
Export Citation:
Assignee:
IP Game Behr
International Classes:
C07J1/00; C12P33/06; C07J5/00; C07J7/00; C07J9/00
Other References:
JPN6012029952; Ｊ． Ｏｒｇ． Ｃｈｅｍ， １９８８， Ｖｏｌ．５３， ｐ．８８-９２
JPN6012029954; Ｅｎｚｙｍｅ Ｍｉｃｒｏｂ． Ｔｅｃｈｎｏｌ．， １９８８， ｖｏｌ．１０， ｐ．３３３-３４０
JPN6012029956; Ａｒｃｈｉｖｅｓ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｐｈｙｓｉｃｓ， １９７３， ｖｏｌ．１５９， ｐ．７-１０
JPN6012029952; Ｊ． Ｏｒｇ． Ｃｈｅｍ， １９８８， Ｖｏｌ．５３， ｐ．８８-９２
JPN6012029954; Ｅｎｚｙｍｅ Ｍｉｃｒｏｂ． Ｔｅｃｈｎｏｌ．， １９８８， ｖｏｌ．１０， ｐ．３３３-３４０
JPN6012029956; Ａｒｃｈｉｖｅｓ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｐｈｙｓｉｃｓ， １９７３， ｖｏｌ．１５９， ｐ．７-１０
JPN6012029954; Ｅｎｚｙｍｅ Ｍｉｃｒｏｂ． Ｔｅｃｈｎｏｌ．， １９８８， ｖｏｌ．１０， ｐ．３３３-３４０
JPN6012029956; Ａｒｃｈｉｖｅｓ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｐｈｙｓｉｃｓ， １９７３， ｖｏｌ．１５９， ｐ．７-１０
JPN6012029952; Ｊ． Ｏｒｇ． Ｃｈｅｍ， １９８８， Ｖｏｌ．５３， ｐ．８８-９２
JPN6012029954; Ｅｎｚｙｍｅ Ｍｉｃｒｏｂ． Ｔｅｃｈｎｏｌ．， １９８８， ｖｏｌ．１０， ｐ．３３３-３４０
JPN6012029956; Ａｒｃｈｉｖｅｓ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｐｈｙｓｉｃｓ， １９７３， ｖｏｌ．１５９， ｐ．７-１０
Attorney, Agent or Firm:
Kenzo Hara International Patent Office