Title:
多分岐ポリマーのプロドラッグ
Document Type and Number:
Japanese Patent JP5632119
Kind Code:
B2
Abstract:
Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise the water-soluble polymer PEG having four arms, which are covalently attached to an active agent, e.g. a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess four active agents releasably attached to a four-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in vivo when compared to unmodified parent drug.
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Inventors:
ツァオ，シュアン
ベントリー，マイケル ディー．
レン，ツォンスー
ビーガス，タセイ エックス．
ベントリー，マイケル ディー．
レン，ツォンスー
ビーガス，タセイ エックス．
Application Number:
JP2006527105A
Publication Date:
November 26, 2014
Filing Date:
September 17, 2004
Export Citation:
Assignee:
ウェルズ ファーゴ バンク ナショナル アソシエイション
International Classes:
A61K47/48; A61K31/4745; A61K31/765; A61K31/785; A61P35/00; C08F8/30; C08G65/333; C08G85/00; C08L71/02
Attorney, Agent or Firm:
Aoki 篤
Ishida 敬
Tetsuji Koga
Yoichi Watanabe
Nakajima 勝
Hiroyasu Suzuki
Satoru Ideno
Atsushi Ebiya
Ishida 敬
Tetsuji Koga
Yoichi Watanabe
Nakajima 勝
Hiroyasu Suzuki
Satoru Ideno
Atsushi Ebiya