Title:
凝血カスケードを選択的に阻害するのに有用な置換された多環式化合物のプロドラッグ
Document Type and Number:
Japanese Patent JP2005509606
Kind Code:
A
Abstract:
The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.
Inventors:
South, Michael Es
Ronald Kay, Webber
Juan, Horn-Chi
Toss, Miharie Vui
Mooreman, Alan Yee
Jeffrey S. Snyder
Shorten, Jeffrey A.
Garland, Danny Jay
Rupel, Melvin El
Neumann, William Elle
Long, scott
Way fan
John the Trujillo
Parlow, John Jay
Dallin Yee, Jones
Case, blender
Hayes, Michael Jay
Zen, Chinpin
Ronald Kay, Webber
Juan, Horn-Chi
Toss, Miharie Vui
Mooreman, Alan Yee
Jeffrey S. Snyder
Shorten, Jeffrey A.
Garland, Danny Jay
Rupel, Melvin El
Neumann, William Elle
Long, scott
Way fan
John the Trujillo
Parlow, John Jay
Dallin Yee, Jones
Case, blender
Hayes, Michael Jay
Zen, Chinpin
Application Number:
JP2003532061A
Publication Date:
April 14, 2005
Filing Date:
October 03, 2002
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
A61K31/4375; A61K31/4965; A61K31/497; A61K31/4985; A61K31/536; A61K31/5377; A61K45/00; A61P7/02; A61P9/00; A61P11/00; A61P43/00; C07C257/18; C07D207/32; C07D211/56; C07D211/98; C07D213/74; C07D231/38; C07D231/48; C07D237/04; C07D239/10; C07D239/22; C07D241/04; C07D241/20; C07D249/14; C07D253/06; C07D253/075; C07D263/48; C07D265/02; C07D277/42; C07D307/22; C07D333/36; C07D401/12; C07D403/10; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D471/04; (IPC1-7): C07D241/20; A61K31/4375; A61K31/4965; A61K31/497; A61K31/4985; A61K31/536; A61K31/5377; A61K45/00; A61P7/02; A61P9/00; A61P11/00; A61P43/00; C07D401/12; C07D405/12; C07D413/12; C07D417/12; C07D471/04
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takako Koiso
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takako Koiso