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Title:
1、4-ジアミノ-2-メトキシメチル-ベンゼンおよびその塩の製造方法、並びにこれらの化合物のケラチン繊維用染色剤としての使用
Document Type and Number:
Japanese Patent JP4293407
Kind Code:
B2
Abstract:
Preparation of 1,4-diamino-2-methoxymethylbenzene (I) and its salts comprises reacting 2-methoxymethyl-4-nitrophenol with haloacetamide to give 2-(2-methoxymethyl-4-nitrophenoxy)acetamide, heating to 80-120 degrees C in DMF, DMAc or NMP with excess of carbonate to give 2-methoxymethyl-4-nitroaniline and catalytically hydrogenating to give (I) and optionally reacting with an acid to give an acid adduct. Preparation of 1,4-diamino-2-methoxymethylbenzene (I) and its salts comprises reacting 2-methoxymethyl-4-nitrophenol with a haloacetamide to give 2-(2-methoxymethyl-4-nitrophenoxy)acetamide, heating to 80-120 degrees C in a solvent from DMF, DMAc and NMP with an excess of carbonate to give 2-methoxymethyl-4-nitroaniline and catalytically hydrogenating to give (I) and optionally reacting with an acid to give an acid adduct when n is not 0. n = 0-2; and HX = (in)organic acid.

Inventors:
Otto Getter
Aline Piero
Andre Hayo
Hans-Jürgen Brown
Application Number:
JP2000311846A
Publication Date:
July 08, 2009
Filing Date:
October 12, 2000
Export Citation:
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Assignee:
WELLA AKTIENGESELLSCHAFT
International Classes:
A61K8/00; A61K8/33; D06P3/08; A61K8/41; A61Q5/10; C07B61/00; C07C213/02; C07C215/68; C07C217/76; C07C231/12; D06P1/38
Foreign References:
US2273564
Attorney, Agent or Firm:
Patent Business Corporation Minori Patent Office
Yasuhiko Takeishi
Noriko Murata