Title:
【発明の名称】選択的にフッ素化された有機化合物の製造方法
Document Type and Number:
Japanese Patent JP2003512342
Kind Code:
A
Abstract:
The present invention provides a method of selectively fluorinating a carbon-hydrogen bond at an unactivated saturated sp<3> hybridised carbon atom of an organic compound, the method including reacting the organic compound with elemental fluorine gas, characterised in that the reaction is carried out in the presence of a basic compound. The method enables the selective transformation of carbon-hydrogen bonds to carbon-fluorine bonds in molecules where the hydrogen atom is attached to a fully saturated unactivated sp<3> hybridised carbon atom such as a tertiary carbon atom found in many saturated hydrocarbon compounds and steroid derivatives. Advantageously, the method may be carried out at or just below room temperature.
Inventors:
Chambers, Richard Dickinson
Parsons, Mandy
Sandford, Graham
Parsons, Mandy
Sandford, Graham
Application Number:
JP2001531765A
Publication Date:
April 02, 2003
Filing Date:
October 16, 2000
Export Citation:
Assignee:
F2 Chemicals Limited
International Classes:
C07B39/00; C07C17/10; C07C19/08; C07C19/10; C07C23/10; C07C23/28; C07C23/36; C07C23/38; C07C67/307; C07C69/63; (IPC1-7): C07C17/10; C07C19/08; C07C19/10; C07C23/10; C07C23/28; C07C23/36; C07C23/38; C07C67/307; C07C69/63
Attorney, Agent or Firm:
Okuyama Shoichi (2 outside)