Title:
【発明の名称】ネチルミシンの製造方法
Document Type and Number:
Japanese Patent JPH0649716
Kind Code:
B2
Abstract:
A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2" positions, and optionally at the 4" position, converting the 1-amino substituents to a 1-N-imino substituent, converting the imino to an ethylamino, deprotecting the compound and recovering netilmicin. Also disclosed are novel intermediate compounds.
Inventors:
TAN CHOOPPON
SURUBENGADAMU TEIRUBETSUTEIPURAMU KANNAPAN
CHIU JON SHEEHAN
KORON SHIIZAA
SURUBENGADAMU TEIRUBETSUTEIPURAMU KANNAPAN
CHIU JON SHEEHAN
KORON SHIIZAA
Application Number:
JP50549686A
Publication Date:
June 29, 1994
Filing Date:
October 14, 1986
Export Citation:
Assignee:
SCHERING PLOUGH CORP
International Classes:
C07H1/00; A61K31/70; A61K31/7028; A61K31/7034; A61K31/7036; A61K31/7135; A61P31/04; C07H15/236; C07H17/04; C07H23/00; C07H; (IPC1-7): C07H15/236
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)
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