Title:
【発明の名称】ステロイド性グリコシドの製造方法
Document Type and Number:
Japanese Patent JP2612123
Kind Code:
B2
Abstract:
Novel glycosides, especially steroidal glycosides, and a novel method of their production, are provided. For the novel method of producing novel glycosides, hydroxysteryl compounds are glycosylated with tri-O-acyl glucal using molecular iodine as a reaction catalyst. In this method an alcohol or phenol, especially a hydroxy-steroid such as a water-insoluble cholesterol, is glycosylated, such that the glycosylation is performed in a single step. The resulting steryl pyranoside is by oxidation converted to the corresponding 7-ketosteryl di-O-acyl-pyranoside. The latter pyranoside is selectively reduced to provide the corresponding 7-(beta)-hydroxysteryl 2,3-dideoxy-(alpha)-D-erythro-hex-2-enopyranoside. The steroidal glycosides obtained in this way possess valuable pharmacological properties. In particular, the glycosides in vivo exhibit a selective cell-destructive activity on malignant cells which activity is substantially free of side effects on normal cells. The glycosides also possess a drive-enhancing (stimulating) activity and an anti-inflammatory (immunosuppressive or immunoregulatory) activity.
Inventors:
KLEMKE RUDOLF ERICH DIPL CHEM (DE)
Application Number:
JP50307891A
Publication Date:
May 21, 1997
Filing Date:
January 22, 1991
Export Citation:
Assignee:
KLEMKE RUDOLF ERICH (DE)
TECHNO BIO KK (JP)
TECHNO BIO KK (JP)
International Classes:
A61K9/06; A61K9/08; A61K9/107; A61K9/02; A61K9/20; A61K9/28; A61K9/48; A61K31/58; A61P25/04; A61P35/00; A61P43/00; C07J17/00; (IPC1-7): C07J17/00; A61K31/58
Other References:
【文献】仏国特許2007410(FR,B)
Attorney, Agent or Firm:
Aoki Akira (3 outside)