Title:
スピロキノン化合物及び医薬組成物
Document Type and Number:
Japanese Patent JP5227803
Kind Code:
B2
Abstract:
A novel spiroquinone derivative having a high ABCA1 stabilization effect and being useful for prophylactic and/or therapeutic agents for various diseases developing hypo-high density lipoproteinemia is obtained. The novel spiroquinone derivative is a compound represented by the following formula:
wherein R 1a , R 1b , R 1c and R each represents a hydrogen atom, a halogen atom, an alkyl group which may have a substituent, or an alkoxy group which may have a substituent, and R 2a and R 2b each represents a hydrogen atom, or an alkyl group which may have a substituent (e.g., a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, and an N-substituted carbamoyl group), the groups R 2a and R 2b may bond together to form a hydrocarbon ring with an adjacent carbon atom, provided that compounds in which all of the groups R 1a , R 1b , R 1c and R 1d are t-butyl groups, and both of the groups R 2a and R 2b are hydrogen atoms or both of the groups R 2a and R 2b are methyl groups are excluded; or a pharmacologically acceptable salt thereof.
Inventors:
Yokoyama Shinji
Kanazawa Hajime
Tomoko Aozuka
Kanazawa Hajime
Tomoko Aozuka
Application Number:
JP2008545430A
Publication Date:
July 03, 2013
Filing Date:
November 21, 2007
Export Citation:
Assignee:
Hikes Laboratories LLC
International Classes:
C07D339/06; A61K31/385; A61P1/00; A61P1/04; A61P1/16; A61P3/04; A61P3/06; A61P5/14; A61P9/00; A61P9/10; A61P13/12; A61P35/00; A61P43/00
Foreign References:
| WO2005067904A1 | 2005-07-28 | |||
| WO2005067904A1 | 2005-07-28 |
Attorney, Agent or Firm:
Mitsuo Kata