Title:
【発明の名称】縮環系キノン誘導体
Document Type and Number:
Japanese Patent JP2599413
Kind Code:
B2
Abstract:
NEW MATERIAL:A cyclocondensation quinone derivative shown by formula I (R<1>, R<2> and R<3> are H, methyl or methoxy; R<4> is hydroxymethyl or carboxyl which may be amidated or esterified; X is H, halogen, lower alkyl or methoxy; Y is CH2 or O) or a hydroquinone derivative thereof. EXAMPLE:1,2,3,4-Tetrahydro-4-(3,4-dimethoxy-6-methyl-2,5-benzoquinonyl )-2- naphthoic acid. USE:A drug useful for improving and treating diseases based on organic disorder in the brain. A small of the drug is orally administered. Low toxicity. PREPARATION:For example, a substituted benzaldehyde is reacted with succinic anhydride to give a butyrolactonecarboxylic acid derivative shown by formula II, which is esterified, reduced and then subjected to ring closure to give a tetralone derivative shown by formula IV. This derivative is reduced and treated with a dehydrating condensation agent to give a lactone shown by formula VI, which is condensed with a hydroquinone derivative shown by formula VII to give a compound shown by formula I wherein Y=CH2.
Inventors:
Toshio Tateoka
Kenji Suzuki
Fumio Sato
Miyano Seiji
Kunihiro Sumoto
Kenji Suzuki
Fumio Sato
Miyano Seiji
Kunihiro Sumoto
Application Number:
JP2186388A
Publication Date:
April 09, 1997
Filing Date:
February 03, 1988
Export Citation:
Assignee:
Suntory Limited
International Classes:
C07C235/82; A61K31/12; A61K31/122; A61K31/165; A61K31/19; A61K31/215; A61K31/35; A61K31/352; A61K31/365; A61K31/495; A61K31/535; A61K31/5375; A61K31/54; A61P25/28; C07C45/00; C07C50/08; C07C50/28; C07C62/38; C07C66/00; C07C67/00; C07C69/757; C07D295/18; C07D307/00; C07D307/32; C07D307/33; C07D311/58; C07D311/68; C07D493/08; (IPC1-7): C07C50/28; C07C66/00; C07C69/757; C07D295/18; C07D311/58
Attorney, Agent or Firm:
Aoki Akira (3 outside)