Title:
放射性薬品化合物、トロパン認識部位の密度検出方法、神経変性または神経精神疾患の監視方法、及び放射性薬品キット
Document Type and Number:
Japanese Patent JP5001480
Kind Code:
B2
Abstract:
Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
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Inventors:
Meltzer, Peter See.
Madras, Versa Kei.
Brandel, Paul
Mahmoud, Ashfark
Jones, Alan Gee.
Fishman, Alan Jay.
Madras, Versa Kei.
Brandel, Paul
Mahmoud, Ashfark
Jones, Alan Gee.
Fishman, Alan Jay.
Application Number:
JP30959999A
Publication Date:
August 15, 2012
Filing Date:
October 29, 1999
Export Citation:
Assignee:
President and Fellows of Harvard College
Organics Incorporated
THE GENERAL HOSPITALCORPORATION
Organics Incorporated
THE GENERAL HOSPITALCORPORATION
International Classes:
A61K31/46; C07D451/02; A61K51/00; A61K51/04; A61P25/00; A61P25/28; A61P43/00; C07F13/00
Foreign References:
| WO1997016210A1 |
Other References:
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J. Nucl. Med.,1999年,40 Supplement,38P、262P
J. Med. Chem.,1997年,40,9-17
Bioorg. Med. Chem.,1998年,6,1663-1672
J. Med. Chem.,1993年,36,855-862
Forschungszent. Rossendorf,1997年,FZR200,33-36
Synapse,1996年,22,239-246
Bioconjugate Chem.,1996年,7,421-429
J. Am. Chem. Soc.,1995年,117,11037-11038
Bioorg. Med. Chem. Lett.,1999年,9,857-862
J. Med. Chem.,1995年,38,379-388
J. Med. Chem.,1994年,37,1262-1268
Med. Chem. Res.,1998年,8,12-34
J. Nucl. Med.,1999年,40 Supplement,38P、262P
J. Med. Chem.,1997年,40,9-17
Bioorg. Med. Chem.,1998年,6,1663-1672
J. Med. Chem.,1993年,36,855-862
Attorney, Agent or Firm:
Akinaka Takano