Title:
化合物のインビボ活性をスクリーニングする迅速な方法
Document Type and Number:
Japanese Patent JP2004517334
Kind Code:
A
Abstract:
The present invention provides a rapid method for screening potentially pharmaceutically useful compounds for activity in vivo. The method has the steps of growing a target cell into which a reporter gene was introduced in a biocompatible, semipermeable encapsulation device; implanting the semi-permeable encapsulation device into a subject; administering a potentially pharmaceutically active compound to said subject; removing said encapsulation device from said subject after in vivo exposure to the potentially pharmaceutically active compound and evaluating said target cell for reaction to said potentially pharmaceutically active compound by measuring the expression of said reporter gene.
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Inventors:
Piotr Lasota
Application Number:
JP2002556788A
Publication Date:
June 10, 2004
Filing Date:
January 08, 2002
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
G01N33/50; A61K49/00; C12N15/09; C12Q1/02; C12Q1/68; G01N21/78; G01N33/15; G01N33/53; (IPC1-7): G01N33/50; C12N15/09; C12Q1/02; C12Q1/68; G01N21/78; G01N33/15; G01N33/53
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima