Title:
A rebirth of the endogenous cardiac muscle tissue by guidance of a new blood vessel rebirth
Document Type and Number:
Japanese Patent JP5911841
Kind Code:
B2
Abstract:
This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject an amount of an agent effective to cause cardiomyocyte proliferation within the subject's heart so as to thereby treat the disorder. This invention further provides the instant method wherein the agent is human endothelial progenitor cells, G-CSF, GM-CSF, SDF-1, and IL-8. This invention also provides methods of determining the susceptibility of a cardiomyocyte in a subject to apoptosis. To be accompanied, when published, by Figure 1B of the drawings.
Inventors:
Silviu Itesque
Application Number:
JP2013249643A
Publication Date:
May 11, 2016
Filing Date:
December 02, 2013
Export Citation:
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
International Classes:
A61K38/22; A61K31/045; C12N15/09; A61K31/7088; A61K31/711; A61K35/32; A61K35/36; A61K38/00; A61K38/18; A61K38/19; A61K39/395; A61K45/00; A61K48/00; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P43/00; C07K16/28; C12N5/071; C12N15/113; C12Q1/02; C12Q1/68; A61K35/12
Foreign References:
| WO2001094420A1 |
Other References:
Dev. Dyn.,1997年,vol. 210,344-353
Junn E et al.,Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function,J Immunol.,2000年 6月15日,164(12),6287-95
斎藤達哉ら,小脳か粒細胞死におけるVitamin D3 Up-regulated Protein 1(VDUP1)mRNAの迅速な発現上昇,神経化学,2001年 9月 1日,Vol.40, No.2/3,,Page.279
Lee WL et al.,Insulin-like growth factor I improves cardiovascular function and suppresses apoptosis of cardiomyoc,Endocrinology.,1999年10月,140(10),4831-40
Saitoh T et al.,Rapid induction and Ca(2+) influx-mediated suppression of vitamin D3 up-regulated protein 1 (VDUP1),J Neurochem.,2001年 9月,78(6),1267-76
Junn E et al.,Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function,J Immunol.,2000年 6月15日,164(12),6287-95
斎藤達哉ら,小脳か粒細胞死におけるVitamin D3 Up-regulated Protein 1(VDUP1)mRNAの迅速な発現上昇,神経化学,2001年 9月 1日,Vol.40, No.2/3,,Page.279
Lee WL et al.,Insulin-like growth factor I improves cardiovascular function and suppresses apoptosis of cardiomyoc,Endocrinology.,1999年10月,140(10),4831-40
Saitoh T et al.,Rapid induction and Ca(2+) influx-mediated suppression of vitamin D3 up-regulated protein 1 (VDUP1),J Neurochem.,2001年 9月,78(6),1267-76
Attorney, Agent or Firm:
Kurata Masatoshi
Nobuhisa Nogawa
Naoki Kono
Tadashi Inoue
Ukai Ken
Nobuhisa Nogawa
Naoki Kono
Tadashi Inoue
Ukai Ken