Title:
The recombination immunity toxin which makes meso Terin a target
Document Type and Number:
Japanese Patent JP6169561
Kind Code:
B2
Abstract:
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to improved recombinant immunotoxins comprising anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and a Pseudomonas Exotoxin moiety which has been modified to reduce its immunogenicity and protease sensitivity and providing a better cytotoxicity for cells which express mesothelin. The RITs are well-suited for the treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
Inventors:
Pastan, Illa H.
Weldon, john
Beards, Richard
Weldon, john
Beards, Richard
Application Number:
JP2014509467A
Publication Date:
July 26, 2017
Filing Date:
May 04, 2012
Export Citation:
Assignee:
The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Man Services
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2008523105A | ||||
| JP2008526889A | ||||
| JP2009514537A |
Foreign References:
| WO2009032954A1 | ||||
| WO2011032022A1 |
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation
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