Title:
The reinforcement method of pluripotency
Document Type and Number:
Japanese Patent JP5939985
Kind Code:
B2
Abstract:
We provide for the use of Tbx3 (GenBank Accession Number: NM_005996.3 (SEQ ID NO. 1), NP_005987.3 (SEQ ID NO. 2), NM_016569.3 (SEQ ID NO. 3), NP_057653.3 (SEQ ID NO. 4)) in a method of enhancing or inducing pluripotency in a cell such as a somatic cell. We describe a method of reprogramming a cell, the method comprising modulating the expression and/or activity of Tbx3 in the cell. The cell may become a pluripotent cell such as a stem cell. We further describe a method of causing a cell such as a somatic cell to display one or more characteristics of a pluripotent cell, the method comprising modulating the expression and/or activity of Tbx3 in the cell. The method may further comprise modulating the expression and/or activity of one or more, a combination of or all of Oct4, Sox2 and Klf4 in the cell.
Inventors:
Rim bin
Han Jiang Young
Tam Wy Leon
Han Jiang Young
Tam Wy Leon
Application Number:
JP2012539856A
Publication Date:
June 29, 2016
Filing Date:
November 18, 2010
Export Citation:
Assignee:
AGENCY FOR SCIENCE,TECHNOLOGY AND RESEARCH
International Classes:
C12N5/10; A61K35/12; A61P43/00; C12Q1/02
Foreign References:
| WO2009057831A1 |
Other References:
Nature, (2009), Vol. 460, p. 118-122
Attorney, Agent or Firm:
Junya Tanaka
Yamada Iichiro
Hiroki Matsui
Tachibana Kenji
Yamashita Unknown
Yamada Iichiro
Hiroki Matsui
Tachibana Kenji
Yamashita Unknown
Previous Patent: Heterorepu -- the use which uses a tick carbene complex and the complex with organic electronics
Next Patent: BLOWER TROUBLE DETECTOR
Next Patent: BLOWER TROUBLE DETECTOR