Title:
レニウム錯体及びその薬学的使用
Document Type and Number:
Japanese Patent JP2013528615
Kind Code:
A
Abstract:
The present invention is directed to a rhenium complex of general Formula (I) or a pharmaceutically acceptable salt or solvate thereof wherein X is chosen from S Se or Te; Y is NH, O or S or is a methylene group; Z is halogen; m = 0,1 , or 2 and p = 0,1 , or 2, provided that m and p are both different from zero when Y is NH, O or S; n = 3; R 1 is a phenyl group or a group of general Formula (CH 2 ) q -COOH wherein q = 1 or 2, a pharmaceutical composition comprising a therapeutically effective amount of at least one of such rhenium complex, a method for preparing said rhenium complex and a method for treating a proliferative growth related-disorder using a therapeutically effective amount of at least one of said rhenium complex. Also claimed are compounds of formula (II).
Inventors:
Corrie, Philip
D'Angelo, Jean
Georges, Morgan
D'Angelo, Jean
Georges, Morgan
Application Number:
JP2013512924A
Publication Date:
July 11, 2013
Filing Date:
June 01, 2011
Export Citation:
Assignee:
Société de Coordination Dulcherche Terraptic
UNIVERSITE PARIS SUD 11
Ecole Polytechnique/Dgar
UNIVERSITE PARIS SUD 11
Ecole Polytechnique/Dgar
International Classes:
C07C391/00; A61K31/28; A61K33/242; A61K33/243; A61K33/244; A61K45/00; A61P35/00; A61P43/00; C07F13/00
Domestic Patent References:
| JP2007509047A | 2007-04-12 | |||
| JPH0391735A | 1991-04-17 | |||
| JP2007509047A | 2007-04-12 | |||
| JPH0391735A | 1991-04-17 |
Foreign References:
| US2657231A | 1953-10-27 | |||
| GB1307227B | ||||
| US2602816A | 1952-07-08 | |||
| US3217004A | 1965-11-09 | |||
| US2657231A | 1953-10-27 | |||
| GB1307227B | ||||
| US2602816A | 1952-07-08 | |||
| US3217004A | 1965-11-09 |
Other References:
JPN6015008889; ＬＩＡＷ，ＷＥＮ-ＦＥＮＧ，ＥＴ ＡＬ．: '"Ｒｈｅｎｉｕｍ（Ｉ） Ｔｅｌｌｕｒｏｌａｔｅ， Ｔｅｌｌｕｒｏｅｔｈｅｒ ａｎｄ Ｂｉｄｅｎｔａｔｅ-Ｔｅｌｌｕｒｏｅｔｈｅｒ Ｃｏｍｐｌｅｘｅｓ： Ｃｒｙｓｔａｌ Ｓｔｒｕｃｔｕｒｅｓ ｏｆ Ｒｅ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＣＨＩＮＥＳＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ （ＴＡＩＰＥＩ） ＶＯＬ．４２，ＮＯ．１, 1995, ＰＰ．５９-６５
JPN6015008890; ＰＩＥＴＺＳＣＨ，Ｈ．-Ｊ．，ＥＴ ＡＬ．: '"Ｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｌｏｇｉｃａｌ Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ Ｔｅｃｈｎｅｔｉｕｍ（Ｉ） ａｎｄ Ｒｈｅｎｉｕｍ（Ｉ） Ｔｒｉｃａｒｂｏｎｙｌ Ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ' ＢＩＯＣＯＮＪＵＧＡＴＥ ＣＨＥＭＩＳＴＲＹ ＶＯＬ．１１，ＮＯ．３, 2000, ＰＰ．４１４-４２４
JPN6015008891; ＨＯＬＭＢＥＲＧ，ＢＲＯＲ: '"Ｏｒｇａｎｉｃ Ｐｏｌｙｓｕｌｐｈｉｄｅｓ"' ＪＵＳＴＵＳ ＬＩＥＢＩＧＳ ＡＮＮＡＬＥＮ ＤＥＲ ＣＨＥＭＩＥ ＶＯＬ．３５９, 1908, ＰＰ．８１-９９
JPN6015008892; ＡＤＤＩＳＯＮ，ＡＮＴＨＯＮＹ Ｗ．，ＥＴ ＡＬ．: '"Ｓｙｎｔｈｅｓｉｓ ｏｆ Ｓｏｍｅ Ｂｅｎｚｉｍｉｄａｚｏｌｅ- ａｎｄ Ｂｅｎｚｏｔｈｉａｚｏｌｅ-Ｄｅｒｉｖｅｄ Ｌｉｇａｎｄ Ｓｙｓｔｅｍｓ ａｎｄ Ｔｈｅｉｒ Ｐｒｅｃｕｒｓｏｒｙ Ｄｉａｃ' ＪＯＵＲＮＡＬ ＯＦ ＨＥＴＥＲＯＣＹＣＬＩＣ ＣＨＥＭＩＳＴＲＹ ＶＯＬ．２０，ＮＯ．６, 1983, ＰＰ．１４８１-１４８４
JPN6015008893; ＢＡＬＩＡＨ，Ｖ．，ＥＴ ＡＬ．: '"Ｓｙｎｔｈｅｓｉｓ ｏｆ ５-Ａｒｙｌ-４，６-ｂｉｓ［ａｌｋｏｘｙｃａｒｂｏｎｙｌ］-１，３-ｄｉｔｈｉａｎｅ１，１，３，３-Ｔｅｔｒｏｘｉｄｅｓ"' ＳＹＮＴＨＥＳＩＳ ＶＯＬ．１２, 1981, ＰＰ．９９５-９９６
JPN6015008894; ＦＲＥＤＧＡ，ＡＲＥＮＡ: '"Ｅｉｎｅ Ｍｅｔｈｏｄｅ ａｕｒ Ｄａｒｓｔｅｌｌｕｎｇ ｖｏｎ Ｃａｒｂｏｎｓａｕｒｅｎ ｏｒｇａｎｉｓｃｈｅｒ Ｓｅｌｅｎｉｄｅ"' ＣＨＥＭＩＳＣＨＥＳ ＺＥＮＴＲＡＬＢＬＡＴＴ ＶＯＬ．１０７, 1936, ＰＰ．１７０４-１７０５
JPN6015008895; ＣＡＳＡＳＳＡＳ，ＥＮＲＩＣ，ＥＴ ＡＬ．: '"Ｃｃｏｍｐｌｅｘｅｓ ｍｅｔａｌｌｉｑｕｅｓ ｄｕ ｂｉｓ［２-［（ｃａｒｂｏｘｙｍｅｔｈｙｌ）ｔｈｉｏ］ｅｔｈｙｌ］ｅｔｈｅｒ"' ＪＯＵＲＮＡＬ ＤＥ ＣＨＩＭＩＥ ＰＨＹＳＩＱＵＥ ＥＴ ＤＥ ＰＨＹＳＩＣＯ-ＣＨＩＭＩＥ ＢＩＯＬＯＧＩＱＵＥ ＶＯＬ．７４，ＮＯ．４, 1977, ＰＰ．４２４-４２６
JPN6015008896; ＬＡＲＳＳＯＮ， ＥＲＩＫ ＥＴ ＡＬ．: '"Ｓｅｖｅｒａｌ ｎｅｗ ｐｏｌｙｍｅｔｈｙｌｅｎｅ（ｂｉｓ-beta-ｍｅｒｃａｐｔｏ ａｃｉｄｓ）"' ＣＨＡＬＭＥＲＳ ＴＥＫＮＩＳＫＡ ＨＯＥＧＳＫＯＬＡＳ ＨＡＮＤＬＩＮＧＡＲ ＮＯ．４７, 1945, ＰＰ．１３-１４
JPN6015008897; ＬＡＢＵＫ，ＰＩＯＴＲ，ＥＴ ＡＬ．: '"Ｒｅａｃｔｉｏｎ ｏｆ ｅｌｅｍｅｎｔａｌ ｓｕｌｆｕｒ ｗｉｔｈ ａｃｒｙｌｏｎｉｔｒｉｌｅ． Ｓｙｎｔｈｅｓｉｓ ｏｆ１，７-ｄｉｃｙａｎｏ-３，４，５-ｔｒｉｔｈｉａｈｅｐｔａｎｅ"' ＰＨＯＳＰＨＯＲＵＳ， ＳＵＬＦＵＲ ＡＮＤ ＳＩＬＩＣＯＮ ＡＮＤ ＴＨＥ ＲＥＬＡＴＥＤ ＥＬＥＭＥＮＴＳ ＶＯＬ．４２，ＮＯ．１-２, 1989, ＰＰ．１０７-１０９
JPN6015008898; ＶＯＲＯＮＫＯＶ，Ｍ． Ｇ．，ＥＴ ＡＬ．: '"Ｐｈｏｔｏｃｈｅｍｉｃａｌ ｒｅａｃｔｉｏｎ ｏｆ ｅｔｈｙｎｙｌｓｉｌａｎｅｓ ｗｉｔｈ ２-ｍｅｒｃａｐｔｏｅｔｈａｎｏｌ ａｎｄ ｔｈｉｏｇｌｙｃｏｌｉｃ ａｃｉｄ"' ＺＨＵＲＮＡＬ ＯＢＳＨＣＨＥＩ ＫＨＩＭＩＩ ＶＯＬ．５８，ＮＯ．８, 1988, ＰＰ．１８２７-１８３１
JPN6015008899; ＡＢＥＬ，ＥＤＷＡＲＤ Ｗ．，ＥＴ ＡＬ．: '"Ａ Ｎｕｃｌｅａｒ Ｍａｇｎｅｔｉｃ Ｒｅｓｏｎａｎｃｅ Ｓｔｕｄｙ ｏｆ Ｐｙｒａｍｉｄａｌ Ａｔｏｍｉｃ Ｉｎｖｅｒｓｉｏｎ ｉｎ Ｃｏｍｐｌｅｘｅｓ ｏｆ Ｔｒｉｃａｒｂｏｎｙｌｒｈｅｎｉｕｍ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ， ＤＡＬＴＯＮ ＴＲＡＮＳＡＣＴＩＯＮＳ： ＩＮＯＲＧＡＮＩＣ ＣＨＥＭＩＳＴＲＹ （１９７２-１９９９） ＮＯ．１０, 1982, ＰＰ．２０６５-２０７２
JPN6015008889; ＬＩＡＷ，ＷＥＮ-ＦＥＮＧ，ＥＴ ＡＬ．: '"Ｒｈｅｎｉｕｍ（Ｉ） Ｔｅｌｌｕｒｏｌａｔｅ， Ｔｅｌｌｕｒｏｅｔｈｅｒ ａｎｄ Ｂｉｄｅｎｔａｔｅ-Ｔｅｌｌｕｒｏｅｔｈｅｒ Ｃｏｍｐｌｅｘｅｓ： Ｃｒｙｓｔａｌ Ｓｔｒｕｃｔｕｒｅｓ ｏｆ Ｒｅ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＣＨＩＮＥＳＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ （ＴＡＩＰＥＩ） ＶＯＬ．４２，ＮＯ．１, 1995, ＰＰ．５９-６５
JPN6015008890; ＰＩＥＴＺＳＣＨ，Ｈ．-Ｊ．，ＥＴ ＡＬ．: '"Ｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｌｏｇｉｃａｌ Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ Ｔｅｃｈｎｅｔｉｕｍ（Ｉ） ａｎｄ Ｒｈｅｎｉｕｍ（Ｉ） Ｔｒｉｃａｒｂｏｎｙｌ Ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ' ＢＩＯＣＯＮＪＵＧＡＴＥ ＣＨＥＭＩＳＴＲＹ ＶＯＬ．１１，ＮＯ．３, 2000, ＰＰ．４１４-４２４
JPN6015008891; ＨＯＬＭＢＥＲＧ，ＢＲＯＲ: '"Ｏｒｇａｎｉｃ Ｐｏｌｙｓｕｌｐｈｉｄｅｓ"' ＪＵＳＴＵＳ ＬＩＥＢＩＧＳ ＡＮＮＡＬＥＮ ＤＥＲ ＣＨＥＭＩＥ ＶＯＬ．３５９, 1908, ＰＰ．８１-９９
JPN6015008892; ＡＤＤＩＳＯＮ，ＡＮＴＨＯＮＹ Ｗ．，ＥＴ ＡＬ．: '"Ｓｙｎｔｈｅｓｉｓ ｏｆ Ｓｏｍｅ Ｂｅｎｚｉｍｉｄａｚｏｌｅ- ａｎｄ Ｂｅｎｚｏｔｈｉａｚｏｌｅ-Ｄｅｒｉｖｅｄ Ｌｉｇａｎｄ Ｓｙｓｔｅｍｓ ａｎｄ Ｔｈｅｉｒ Ｐｒｅｃｕｒｓｏｒｙ Ｄｉａｃ' ＪＯＵＲＮＡＬ ＯＦ ＨＥＴＥＲＯＣＹＣＬＩＣ ＣＨＥＭＩＳＴＲＹ ＶＯＬ．２０，ＮＯ．６, 1983, ＰＰ．１４８１-１４８４
JPN6015008893; ＢＡＬＩＡＨ，Ｖ．，ＥＴ ＡＬ．: '"Ｓｙｎｔｈｅｓｉｓ ｏｆ ５-Ａｒｙｌ-４，６-ｂｉｓ［ａｌｋｏｘｙｃａｒｂｏｎｙｌ］-１，３-ｄｉｔｈｉａｎｅ１，１，３，３-Ｔｅｔｒｏｘｉｄｅｓ"' ＳＹＮＴＨＥＳＩＳ ＶＯＬ．１２, 1981, ＰＰ．９９５-９９６
JPN6015008894; ＦＲＥＤＧＡ，ＡＲＥＮＡ: '"Ｅｉｎｅ Ｍｅｔｈｏｄｅ ａｕｒ Ｄａｒｓｔｅｌｌｕｎｇ ｖｏｎ Ｃａｒｂｏｎｓａｕｒｅｎ ｏｒｇａｎｉｓｃｈｅｒ Ｓｅｌｅｎｉｄｅ"' ＣＨＥＭＩＳＣＨＥＳ ＺＥＮＴＲＡＬＢＬＡＴＴ ＶＯＬ．１０７, 1936, ＰＰ．１７０４-１７０５
JPN6015008895; ＣＡＳＡＳＳＡＳ，ＥＮＲＩＣ，ＥＴ ＡＬ．: '"Ｃｃｏｍｐｌｅｘｅｓ ｍｅｔａｌｌｉｑｕｅｓ ｄｕ ｂｉｓ［２-［（ｃａｒｂｏｘｙｍｅｔｈｙｌ）ｔｈｉｏ］ｅｔｈｙｌ］ｅｔｈｅｒ"' ＪＯＵＲＮＡＬ ＤＥ ＣＨＩＭＩＥ ＰＨＹＳＩＱＵＥ ＥＴ ＤＥ ＰＨＹＳＩＣＯ-ＣＨＩＭＩＥ ＢＩＯＬＯＧＩＱＵＥ ＶＯＬ．７４，ＮＯ．４, 1977, ＰＰ．４２４-４２６
JPN6015008896; ＬＡＲＳＳＯＮ， ＥＲＩＫ ＥＴ ＡＬ．: '"Ｓｅｖｅｒａｌ ｎｅｗ ｐｏｌｙｍｅｔｈｙｌｅｎｅ（ｂｉｓ-beta-ｍｅｒｃａｐｔｏ ａｃｉｄｓ）"' ＣＨＡＬＭＥＲＳ ＴＥＫＮＩＳＫＡ ＨＯＥＧＳＫＯＬＡＳ ＨＡＮＤＬＩＮＧＡＲ ＮＯ．４７, 1945, ＰＰ．１３-１４
JPN6015008897; ＬＡＢＵＫ，ＰＩＯＴＲ，ＥＴ ＡＬ．: '"Ｒｅａｃｔｉｏｎ ｏｆ ｅｌｅｍｅｎｔａｌ ｓｕｌｆｕｒ ｗｉｔｈ ａｃｒｙｌｏｎｉｔｒｉｌｅ． Ｓｙｎｔｈｅｓｉｓ ｏｆ１，７-ｄｉｃｙａｎｏ-３，４，５-ｔｒｉｔｈｉａｈｅｐｔａｎｅ"' ＰＨＯＳＰＨＯＲＵＳ， ＳＵＬＦＵＲ ＡＮＤ ＳＩＬＩＣＯＮ ＡＮＤ ＴＨＥ ＲＥＬＡＴＥＤ ＥＬＥＭＥＮＴＳ ＶＯＬ．４２，ＮＯ．１-２, 1989, ＰＰ．１０７-１０９
JPN6015008898; ＶＯＲＯＮＫＯＶ，Ｍ． Ｇ．，ＥＴ ＡＬ．: '"Ｐｈｏｔｏｃｈｅｍｉｃａｌ ｒｅａｃｔｉｏｎ ｏｆ ｅｔｈｙｎｙｌｓｉｌａｎｅｓ ｗｉｔｈ ２-ｍｅｒｃａｐｔｏｅｔｈａｎｏｌ ａｎｄ ｔｈｉｏｇｌｙｃｏｌｉｃ ａｃｉｄ"' ＺＨＵＲＮＡＬ ＯＢＳＨＣＨＥＩ ＫＨＩＭＩＩ ＶＯＬ．５８，ＮＯ．８, 1988, ＰＰ．１８２７-１８３１
JPN6015008899; ＡＢＥＬ，ＥＤＷＡＲＤ Ｗ．，ＥＴ ＡＬ．: '"Ａ Ｎｕｃｌｅａｒ Ｍａｇｎｅｔｉｃ Ｒｅｓｏｎａｎｃｅ Ｓｔｕｄｙ ｏｆ Ｐｙｒａｍｉｄａｌ Ａｔｏｍｉｃ Ｉｎｖｅｒｓｉｏｎ ｉｎ Ｃｏｍｐｌｅｘｅｓ ｏｆ Ｔｒｉｃａｒｂｏｎｙｌｒｈｅｎｉｕｍ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ， ＤＡＬＴＯＮ ＴＲＡＮＳＡＣＴＩＯＮＳ： ＩＮＯＲＧＡＮＩＣ ＣＨＥＭＩＳＴＲＹ （１９７２-１９９９） ＮＯ．１０, 1982, ＰＰ．２０６５-２０７２
JPN6015008890; ＰＩＥＴＺＳＣＨ，Ｈ．-Ｊ．，ＥＴ ＡＬ．: '"Ｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｌｏｇｉｃａｌ Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ Ｔｅｃｈｎｅｔｉｕｍ（Ｉ） ａｎｄ Ｒｈｅｎｉｕｍ（Ｉ） Ｔｒｉｃａｒｂｏｎｙｌ Ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ' ＢＩＯＣＯＮＪＵＧＡＴＥ ＣＨＥＭＩＳＴＲＹ ＶＯＬ．１１，ＮＯ．３, 2000, ＰＰ．４１４-４２４
JPN6015008891; ＨＯＬＭＢＥＲＧ，ＢＲＯＲ: '"Ｏｒｇａｎｉｃ Ｐｏｌｙｓｕｌｐｈｉｄｅｓ"' ＪＵＳＴＵＳ ＬＩＥＢＩＧＳ ＡＮＮＡＬＥＮ ＤＥＲ ＣＨＥＭＩＥ ＶＯＬ．３５９, 1908, ＰＰ．８１-９９
JPN6015008892; ＡＤＤＩＳＯＮ，ＡＮＴＨＯＮＹ Ｗ．，ＥＴ ＡＬ．: '"Ｓｙｎｔｈｅｓｉｓ ｏｆ Ｓｏｍｅ Ｂｅｎｚｉｍｉｄａｚｏｌｅ- ａｎｄ Ｂｅｎｚｏｔｈｉａｚｏｌｅ-Ｄｅｒｉｖｅｄ Ｌｉｇａｎｄ Ｓｙｓｔｅｍｓ ａｎｄ Ｔｈｅｉｒ Ｐｒｅｃｕｒｓｏｒｙ Ｄｉａｃ' ＪＯＵＲＮＡＬ ＯＦ ＨＥＴＥＲＯＣＹＣＬＩＣ ＣＨＥＭＩＳＴＲＹ ＶＯＬ．２０，ＮＯ．６, 1983, ＰＰ．１４８１-１４８４
JPN6015008893; ＢＡＬＩＡＨ，Ｖ．，ＥＴ ＡＬ．: '"Ｓｙｎｔｈｅｓｉｓ ｏｆ ５-Ａｒｙｌ-４，６-ｂｉｓ［ａｌｋｏｘｙｃａｒｂｏｎｙｌ］-１，３-ｄｉｔｈｉａｎｅ１，１，３，３-Ｔｅｔｒｏｘｉｄｅｓ"' ＳＹＮＴＨＥＳＩＳ ＶＯＬ．１２, 1981, ＰＰ．９９５-９９６
JPN6015008894; ＦＲＥＤＧＡ，ＡＲＥＮＡ: '"Ｅｉｎｅ Ｍｅｔｈｏｄｅ ａｕｒ Ｄａｒｓｔｅｌｌｕｎｇ ｖｏｎ Ｃａｒｂｏｎｓａｕｒｅｎ ｏｒｇａｎｉｓｃｈｅｒ Ｓｅｌｅｎｉｄｅ"' ＣＨＥＭＩＳＣＨＥＳ ＺＥＮＴＲＡＬＢＬＡＴＴ ＶＯＬ．１０７, 1936, ＰＰ．１７０４-１７０５
JPN6015008895; ＣＡＳＡＳＳＡＳ，ＥＮＲＩＣ，ＥＴ ＡＬ．: '"Ｃｃｏｍｐｌｅｘｅｓ ｍｅｔａｌｌｉｑｕｅｓ ｄｕ ｂｉｓ［２-［（ｃａｒｂｏｘｙｍｅｔｈｙｌ）ｔｈｉｏ］ｅｔｈｙｌ］ｅｔｈｅｒ"' ＪＯＵＲＮＡＬ ＤＥ ＣＨＩＭＩＥ ＰＨＹＳＩＱＵＥ ＥＴ ＤＥ ＰＨＹＳＩＣＯ-ＣＨＩＭＩＥ ＢＩＯＬＯＧＩＱＵＥ ＶＯＬ．７４，ＮＯ．４, 1977, ＰＰ．４２４-４２６
JPN6015008896; ＬＡＲＳＳＯＮ， ＥＲＩＫ ＥＴ ＡＬ．: '"Ｓｅｖｅｒａｌ ｎｅｗ ｐｏｌｙｍｅｔｈｙｌｅｎｅ（ｂｉｓ-beta-ｍｅｒｃａｐｔｏ ａｃｉｄｓ）"' ＣＨＡＬＭＥＲＳ ＴＥＫＮＩＳＫＡ ＨＯＥＧＳＫＯＬＡＳ ＨＡＮＤＬＩＮＧＡＲ ＮＯ．４７, 1945, ＰＰ．１３-１４
JPN6015008897; ＬＡＢＵＫ，ＰＩＯＴＲ，ＥＴ ＡＬ．: '"Ｒｅａｃｔｉｏｎ ｏｆ ｅｌｅｍｅｎｔａｌ ｓｕｌｆｕｒ ｗｉｔｈ ａｃｒｙｌｏｎｉｔｒｉｌｅ． Ｓｙｎｔｈｅｓｉｓ ｏｆ１，７-ｄｉｃｙａｎｏ-３，４，５-ｔｒｉｔｈｉａｈｅｐｔａｎｅ"' ＰＨＯＳＰＨＯＲＵＳ， ＳＵＬＦＵＲ ＡＮＤ ＳＩＬＩＣＯＮ ＡＮＤ ＴＨＥ ＲＥＬＡＴＥＤ ＥＬＥＭＥＮＴＳ ＶＯＬ．４２，ＮＯ．１-２, 1989, ＰＰ．１０７-１０９
JPN6015008898; ＶＯＲＯＮＫＯＶ，Ｍ． Ｇ．，ＥＴ ＡＬ．: '"Ｐｈｏｔｏｃｈｅｍｉｃａｌ ｒｅａｃｔｉｏｎ ｏｆ ｅｔｈｙｎｙｌｓｉｌａｎｅｓ ｗｉｔｈ ２-ｍｅｒｃａｐｔｏｅｔｈａｎｏｌ ａｎｄ ｔｈｉｏｇｌｙｃｏｌｉｃ ａｃｉｄ"' ＺＨＵＲＮＡＬ ＯＢＳＨＣＨＥＩ ＫＨＩＭＩＩ ＶＯＬ．５８，ＮＯ．８, 1988, ＰＰ．１８２７-１８３１
JPN6015008899; ＡＢＥＬ，ＥＤＷＡＲＤ Ｗ．，ＥＴ ＡＬ．: '"Ａ Ｎｕｃｌｅａｒ Ｍａｇｎｅｔｉｃ Ｒｅｓｏｎａｎｃｅ Ｓｔｕｄｙ ｏｆ Ｐｙｒａｍｉｄａｌ Ａｔｏｍｉｃ Ｉｎｖｅｒｓｉｏｎ ｉｎ Ｃｏｍｐｌｅｘｅｓ ｏｆ Ｔｒｉｃａｒｂｏｎｙｌｒｈｅｎｉｕｍ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ， ＤＡＬＴＯＮ ＴＲＡＮＳＡＣＴＩＯＮＳ： ＩＮＯＲＧＡＮＩＣ ＣＨＥＭＩＳＴＲＹ （１９７２-１９９９） ＮＯ．１０, 1982, ＰＰ．２０６５-２０７２
JPN6015008889; ＬＩＡＷ，ＷＥＮ-ＦＥＮＧ，ＥＴ ＡＬ．: '"Ｒｈｅｎｉｕｍ（Ｉ） Ｔｅｌｌｕｒｏｌａｔｅ， Ｔｅｌｌｕｒｏｅｔｈｅｒ ａｎｄ Ｂｉｄｅｎｔａｔｅ-Ｔｅｌｌｕｒｏｅｔｈｅｒ Ｃｏｍｐｌｅｘｅｓ： Ｃｒｙｓｔａｌ Ｓｔｒｕｃｔｕｒｅｓ ｏｆ Ｒｅ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＣＨＩＮＥＳＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ （ＴＡＩＰＥＩ） ＶＯＬ．４２，ＮＯ．１, 1995, ＰＰ．５９-６５
JPN6015008890; ＰＩＥＴＺＳＣＨ，Ｈ．-Ｊ．，ＥＴ ＡＬ．: '"Ｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｌｏｇｉｃａｌ Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ Ｔｅｃｈｎｅｔｉｕｍ（Ｉ） ａｎｄ Ｒｈｅｎｉｕｍ（Ｉ） Ｔｒｉｃａｒｂｏｎｙｌ Ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ' ＢＩＯＣＯＮＪＵＧＡＴＥ ＣＨＥＭＩＳＴＲＹ ＶＯＬ．１１，ＮＯ．３, 2000, ＰＰ．４１４-４２４
JPN6015008891; ＨＯＬＭＢＥＲＧ，ＢＲＯＲ: '"Ｏｒｇａｎｉｃ Ｐｏｌｙｓｕｌｐｈｉｄｅｓ"' ＪＵＳＴＵＳ ＬＩＥＢＩＧＳ ＡＮＮＡＬＥＮ ＤＥＲ ＣＨＥＭＩＥ ＶＯＬ．３５９, 1908, ＰＰ．８１-９９
JPN6015008892; ＡＤＤＩＳＯＮ，ＡＮＴＨＯＮＹ Ｗ．，ＥＴ ＡＬ．: '"Ｓｙｎｔｈｅｓｉｓ ｏｆ Ｓｏｍｅ Ｂｅｎｚｉｍｉｄａｚｏｌｅ- ａｎｄ Ｂｅｎｚｏｔｈｉａｚｏｌｅ-Ｄｅｒｉｖｅｄ Ｌｉｇａｎｄ Ｓｙｓｔｅｍｓ ａｎｄ Ｔｈｅｉｒ Ｐｒｅｃｕｒｓｏｒｙ Ｄｉａｃ' ＪＯＵＲＮＡＬ ＯＦ ＨＥＴＥＲＯＣＹＣＬＩＣ ＣＨＥＭＩＳＴＲＹ ＶＯＬ．２０，ＮＯ．６, 1983, ＰＰ．１４８１-１４８４
JPN6015008893; ＢＡＬＩＡＨ，Ｖ．，ＥＴ ＡＬ．: '"Ｓｙｎｔｈｅｓｉｓ ｏｆ ５-Ａｒｙｌ-４，６-ｂｉｓ［ａｌｋｏｘｙｃａｒｂｏｎｙｌ］-１，３-ｄｉｔｈｉａｎｅ１，１，３，３-Ｔｅｔｒｏｘｉｄｅｓ"' ＳＹＮＴＨＥＳＩＳ ＶＯＬ．１２, 1981, ＰＰ．９９５-９９６
JPN6015008894; ＦＲＥＤＧＡ，ＡＲＥＮＡ: '"Ｅｉｎｅ Ｍｅｔｈｏｄｅ ａｕｒ Ｄａｒｓｔｅｌｌｕｎｇ ｖｏｎ Ｃａｒｂｏｎｓａｕｒｅｎ ｏｒｇａｎｉｓｃｈｅｒ Ｓｅｌｅｎｉｄｅ"' ＣＨＥＭＩＳＣＨＥＳ ＺＥＮＴＲＡＬＢＬＡＴＴ ＶＯＬ．１０７, 1936, ＰＰ．１７０４-１７０５
JPN6015008895; ＣＡＳＡＳＳＡＳ，ＥＮＲＩＣ，ＥＴ ＡＬ．: '"Ｃｃｏｍｐｌｅｘｅｓ ｍｅｔａｌｌｉｑｕｅｓ ｄｕ ｂｉｓ［２-［（ｃａｒｂｏｘｙｍｅｔｈｙｌ）ｔｈｉｏ］ｅｔｈｙｌ］ｅｔｈｅｒ"' ＪＯＵＲＮＡＬ ＤＥ ＣＨＩＭＩＥ ＰＨＹＳＩＱＵＥ ＥＴ ＤＥ ＰＨＹＳＩＣＯ-ＣＨＩＭＩＥ ＢＩＯＬＯＧＩＱＵＥ ＶＯＬ．７４，ＮＯ．４, 1977, ＰＰ．４２４-４２６
JPN6015008896; ＬＡＲＳＳＯＮ， ＥＲＩＫ ＥＴ ＡＬ．: '"Ｓｅｖｅｒａｌ ｎｅｗ ｐｏｌｙｍｅｔｈｙｌｅｎｅ（ｂｉｓ-beta-ｍｅｒｃａｐｔｏ ａｃｉｄｓ）"' ＣＨＡＬＭＥＲＳ ＴＥＫＮＩＳＫＡ ＨＯＥＧＳＫＯＬＡＳ ＨＡＮＤＬＩＮＧＡＲ ＮＯ．４７, 1945, ＰＰ．１３-１４
JPN6015008897; ＬＡＢＵＫ，ＰＩＯＴＲ，ＥＴ ＡＬ．: '"Ｒｅａｃｔｉｏｎ ｏｆ ｅｌｅｍｅｎｔａｌ ｓｕｌｆｕｒ ｗｉｔｈ ａｃｒｙｌｏｎｉｔｒｉｌｅ． Ｓｙｎｔｈｅｓｉｓ ｏｆ１，７-ｄｉｃｙａｎｏ-３，４，５-ｔｒｉｔｈｉａｈｅｐｔａｎｅ"' ＰＨＯＳＰＨＯＲＵＳ， ＳＵＬＦＵＲ ＡＮＤ ＳＩＬＩＣＯＮ ＡＮＤ ＴＨＥ ＲＥＬＡＴＥＤ ＥＬＥＭＥＮＴＳ ＶＯＬ．４２，ＮＯ．１-２, 1989, ＰＰ．１０７-１０９
JPN6015008898; ＶＯＲＯＮＫＯＶ，Ｍ． Ｇ．，ＥＴ ＡＬ．: '"Ｐｈｏｔｏｃｈｅｍｉｃａｌ ｒｅａｃｔｉｏｎ ｏｆ ｅｔｈｙｎｙｌｓｉｌａｎｅｓ ｗｉｔｈ ２-ｍｅｒｃａｐｔｏｅｔｈａｎｏｌ ａｎｄ ｔｈｉｏｇｌｙｃｏｌｉｃ ａｃｉｄ"' ＺＨＵＲＮＡＬ ＯＢＳＨＣＨＥＩ ＫＨＩＭＩＩ ＶＯＬ．５８，ＮＯ．８, 1988, ＰＰ．１８２７-１８３１
JPN6015008899; ＡＢＥＬ，ＥＤＷＡＲＤ Ｗ．，ＥＴ ＡＬ．: '"Ａ Ｎｕｃｌｅａｒ Ｍａｇｎｅｔｉｃ Ｒｅｓｏｎａｎｃｅ Ｓｔｕｄｙ ｏｆ Ｐｙｒａｍｉｄａｌ Ａｔｏｍｉｃ Ｉｎｖｅｒｓｉｏｎ ｉｎ Ｃｏｍｐｌｅｘｅｓ ｏｆ Ｔｒｉｃａｒｂｏｎｙｌｒｈｅｎｉｕｍ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ， ＤＡＬＴＯＮ ＴＲＡＮＳＡＣＴＩＯＮＳ： ＩＮＯＲＧＡＮＩＣ ＣＨＥＭＩＳＴＲＹ （１９７２-１９９９） ＮＯ．１０, 1982, ＰＰ．２０６５-２０７２
Attorney, Agent or Firm:
Atomi International Patent Office