Title:
【発明の名称】超音波検査法のための強化剤としての安定性微小泡懸濁液
Document Type and Number:
Japanese Patent JP3135919
Kind Code:
B2
Abstract:
Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
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Inventors:
Schneider, michael
Brocho, Jean
Peziniere, Jerome
Yang, Feng
Brocho, Jean
Peziniere, Jerome
Yang, Feng
Application Number:
JP50757794A
Publication Date:
February 19, 2001
Filing Date:
October 21, 1993
Export Citation:
Assignee:
Blackco International Besloten Fennaught Shap
International Classes:
A61B8/08; A61B8/12; A61B8/13; A61K47/24; A61K9/127; A61K49/00; A61K49/22; B01F3/04; B01J13/02; (IPC1-7): A61K49/00; A61K9/127; A61K47/24
Other References:
【文献】国際公開91/15244(WO,A1)
Attorney, Agent or Firm:
Takashi Ishida (2 outside)