Title:
【発明の名称】抗腫瘍剤としてのビス(アクリジンカルボキサミド)及びビス(フェナジンカルボキサミド)
Document Type and Number:
Japanese Patent JP2001503399
Kind Code:
A
Abstract:
PCT No. PCT/GB97/02886 Sec. 371 Date Jun. 18, 1999 Sec. 102(e) Date Jun. 18, 1999 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17650 PCT Pub. Date Apr. 30, 1998A compound which is a bis(acridinecarboxamide) or bis(phenazinecarboxamide) derivative of formula (I): wherein each X, which may be the same or different in a given molecule, is -CH= or -N= each of R1 to R4 which may be the same or different, H, C1-C4 alkyl, OH, SH, NH2, C1-C4 alkoxy, aryloxy, NHR, N(R)2, SR, SO2R wherein R is C1-C4 alkyl, CF3, NO2 or halogen, or R1 and R2 together form a methylenedioxy group; each of R5 and R6, which may be the same or different, is H or C1-C4 alkyl; Z is (CH2)n, (CH2)nO(CH2)n, (CH2)nN(R7)(CH2)n, (CH2)nN(R7)(CH2)mN(R7)(CH2)n or (CH2)nN(CH2CH2)2N(CH2)n wherein R7 is H or C1-C4 alkyl and n and m, which may be the same or different, are each an integer of 1 to 4; or a pharmaceutically acceptable acid addition salt or N-oxide thereof; has activity as an antitumor and antibacterial agent.
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Inventors:
Denny William Alexander
Game Swarna Rasa Akritaya
Spicer Julie Ann
Bagley Bruce Charles
Finlay Graeme John
Game Swarna Rasa Akritaya
Spicer Julie Ann
Bagley Bruce Charles
Finlay Graeme John
Application Number:
JP51910998A
Publication Date:
March 13, 2001
Filing Date:
October 17, 1997
Export Citation:
Assignee:
Zenova Limited
International Classes:
A61K31/435; A61K31/473; A61K31/495; A61K31/498; A61P35/00; C07C227/18; C07D219/04; C07D241/46; C07C229/58; (IPC1-7): C07D219/04; A61K31/473; A61P35/00; C07D241/46
Attorney, Agent or Firm:
Eiji Saegusa (8 others)